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4QIN

Structure of the human smoothened receptor in complex with SAG1.5

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ASmoothened homolog/Soluble cytochrome b562 chimeric proteinpolymer46852395.21UniProt (Q99835)
UniProt (P0ABE7)
Pfam (PF01534)
Pfam (PF07361)
In PDB
Homo sapiens
2A3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamidenon-polymer526.01Chemie (SG8)
3waterwater18.07Chemie (HOH)
Sequence modifications
A: 190 - 433 (UniProt: Q99835)
PDBExternal DatabaseDetails
Gly 187-expression tag
Gly 188-expression tag
Thr 189-expression tag
A: 1001 - 1106 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Trp 1007Met 29engineered mutation
Ile 1102His 124engineered mutation
Leu 1106Arg 128engineered mutation
A: 441 - 555 (UniProt: Q99835)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight52395.2
Non-Polymers*Number of molecules1
Total formula weight526.0
All*Total formula weight52921.2
*Water molecules are not included.

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PDB entries from 2024-09-18

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