Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QIM

Structure of the human smoothened receptor in complex with ANTA XV

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005506	molecular_function	iron ion binding
A	0007166	biological_process	cell surface receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE A8T A 1201

Chain	Residue
A	ASN219
A	HIS470
A	ASP473
A	GLN477
A	GLU518
A	ASN521
A	LEU221
A	TRP281
A	ASP384
A	VAL386
A	PHE391
A	TYR394
A	LYS395
A	ARG400

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1202

Chain	Residue
A	HIS433
A	ASP1021
A	HOH1311
A	HOH1312

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	13
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	90
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)