6XBM

Structure of human SMO-Gi complex with 24(S),25-EC

Summary for 6XBM

• Entry DOI: 10.2210/pdb6xbm/pdb
• EMDB information: 22120
• Descriptor: Smoothened homolog, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 186319.88

Authors

Qi, X.,Long, T.,Li, X. (deposition date: 2020-06-06, release date: 2020-09-30, Last modification date: 2020-11-25)

• Primary citation: Qi, X.,Friedberg, L.,De Bose-Boyd, R.,Long, T.,Li, X.; Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.; Nat.Chem.Biol., 16:1368-1375, 2020; PubMed: 32929279; DOI: 10.1038/s41589-020-0646-2

Experimental method

ELECTRON MICROSCOPY (3.15 Å)