6XBM
Structure of human SMO-Gi complex with 24(S),25-EC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Smoothened homolog | polymer | 652 | 71786.4 | 1 | UniProt (Q99835) Pfam (PF01392) Pfam (PF01534) | Homo sapiens (Human) | SMO,Protein Gx |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (Human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 5 | E (S) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
| 6 | F, G (R) | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL | non-polymer | 400.6 | 2 | Chemie (CO1) PubChem (16759976) PubChem (44302258) PubChem (20610833) PubChem (50987447) PubChem (56947093) PubChem (3247059) PubChem (9887255) PubChem (10237666) PubChem (10250418) PubChem (15597289) PubChem (15597290) PubChem (16064712) PubChem (171318093) PubChem (126969898) PubChem (126969901) PubChem (142521819) PubChem (146159722) PubChem (162950489) PubChem (168322791) PubChem (169439820) PubChem (174841758) |
Sequence modifications
R: 1 - 644 (UniProt: Q99835)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp 645 | - | expression tag |
| Tyr 646 | - | expression tag |
| Lys 647 | - | expression tag |
| Asp 648 | - | expression tag |
| Asp 649 | - | expression tag |
| Asp 650 | - | expression tag |
| Asp 651 | - | expression tag |
| Lys 652 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 185518.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 801.3 | |
| All* | Total formula weight | 186319.9 |
