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7BII
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BU of 7bii by Molmil
Crystal structure of Nematocida HUWE1
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Grabarczyk, D.B, Petrova, O.A, Meinhart, A, Kessler, D, Clausen, T.
登録日2021-01-12
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.037 Å)
主引用文献HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Nat.Chem.Biol., 17, 2021
8BJA
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BU of 8bja by Molmil
Structure of the human UBR5 Dimer.
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Hodakova, Z, Grishkovskaya, I, Haselbach, D.
登録日2022-11-03
公開日2023-07-12
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
Embo J., 42, 2023
8C06
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Structure of Dimeric HECT E3 Ubiquitin Ligase UBR5
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Hehl, L.A, Prabu, J.R, Schulman, B.A.
登録日2022-12-16
公開日2023-08-23
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Nat.Chem.Biol., 20, 2024
8PWL
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BU of 8pwl by Molmil
Cryo-EM structure of a full-length HACE1 dimer
分子名称: E3 ubiquitin-protein ligase HACE1
著者Duering, J, Wolter, M, Dienemann, C, Lorenz, S.
登録日2023-07-20
公開日2024-01-10
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (4.73 Å)
主引用文献Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1.
Nat.Struct.Mol.Biol., 31, 2024
7NH3
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BU of 7nh3 by Molmil
Nematocida Huwe1 in open conformation.
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Petrova, O, Grishkovskaya, I, Grabarczyk, D.B, Kessler, D, Haselbach, D, Clausen, T.
登録日2021-02-09
公開日2022-03-02
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (6.37 Å)
主引用文献Crystal structure of HUWE1: One ring to ubiquitinate them all
To Be Published
8H8X
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BU of 8h8x by Molmil
Cryo-EM structure of HACE1 monomer
分子名称: E3 ubiquitin-protein ligase HACE1
著者Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J.
登録日2022-10-24
公開日2023-06-28
最終更新日2024-01-10
実験手法ELECTRON MICROSCOPY (3.92 Å)
主引用文献Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization.
Adv Sci, 10, 2023
8HAE
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BU of 8hae by Molmil
Cryo-EM structure of HACE1 dimer
分子名称: E3 ubiquitin-protein ligase HACE1
著者Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J, Machida, S.
登録日2022-10-26
公開日2023-06-28
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (4.55 Å)
主引用文献Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization.
Adv Sci, 10, 2023
8P82
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Cryo-EM structure of dimeric UBR5
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H.
登録日2023-05-31
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
To Be Published
8P83
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Cryo-EM structure of full-length human UBR5 (homotetramer)
分子名称: E3 ubiquitin-protein ligase UBR5
著者Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H.
登録日2023-05-31
公開日2023-06-14
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol.Cell, 83, 2023
8D4X
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BU of 8d4x by Molmil
Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a dimeric form
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Wang, F, He, Q, Lin, G, Li, H.
登録日2022-06-02
公開日2023-04-19
最終更新日2023-05-17
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
8E0Q
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BU of 8e0q by Molmil
Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a C2 symmetric dimeric form
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Wang, F, He, Q, Lin, G, Li, H.
登録日2022-08-09
公開日2023-04-19
最終更新日2023-05-17
実験手法ELECTRON MICROSCOPY (2.66 Å)
主引用文献Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
8EWI
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BU of 8ewi by Molmil
Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Wang, F, He, Q, Lin, G, Li, H.
登録日2022-10-23
公開日2023-04-19
最終更新日2023-05-17
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
6XZ1
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BU of 6xz1 by Molmil
Conjugate of the HECT domain of HUWE1 with ubiquitin
分子名称: HECT, UBA and WWE domain containing 1, isoform CRA_a, ...
著者Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S.
登録日2020-01-31
公開日2021-08-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Acs Chem.Biol., 16, 2021
6FYH
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BU of 6fyh by Molmil
Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1
分子名称: E3 ubiquitin-protein ligase HUWE1, Polyubiquitin-B, SULFATE ION, ...
著者Jaeckl, M, Hartmann, M.D, Wiesner, S.
登録日2018-03-12
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.906 Å)
主引用文献beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.
J. Mol. Biol., 430, 2018
7JQ9
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BU of 7jq9 by Molmil
Cryo-EM structure of human HUWE1
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Hunkeler, M, Fischer, E.S.
登録日2020-08-10
公開日2021-07-28
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
4LCD
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BU of 4lcd by Molmil
Structure of an Rsp5xUbxSna3 complex: Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
分子名称: E3 ubiquitin-protein ligase RSP5, Protein SNA3, Ubiquitin
著者Kamadurai, H.B, Miller, D, Schulman, B.A.
登録日2013-06-21
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.
Elife, 2, 2013
3JW0
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BU of 3jw0 by Molmil
E2~Ubiquitin-HECT
分子名称: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2
著者Kamadurai, H.B, Schulman, B.A.
登録日2009-09-17
公開日2010-01-12
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.
Mol.Cell, 36, 2009
2XBB
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BU of 2xbb by Molmil
Nedd4 HECT:Ub complex
分子名称: E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN
著者Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S.
登録日2010-04-08
公開日2011-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
5XMC
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BU of 5xmc by Molmil
Crystal structure of the auto-inhibited Nedd4 family E3 ligase Itch
分子名称: E3 ubiquitin-protein ligase Itchy
著者Shan, Z, Wen, W.
登録日2017-05-13
公開日2017-08-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch
EMBO Rep., 18, 2017
3JVZ
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BU of 3jvz by Molmil
E2~Ubiquitin-HECT
分子名称: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2
著者Souphron, J, Kamadurai, H.B, Schulman, B.A.
登録日2009-09-17
公開日2010-01-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.
Mol.Cell, 36, 2009
1C4Z
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BU of 1c4z by Molmil
STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY
分子名称: UBIQUITIN CONJUGATING ENZYME E2, UBIQUITIN-PROTEIN LIGASE E3A
著者Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P.
登録日1999-10-14
公開日1999-11-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Science, 286, 1999
4BBN
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BU of 4bbn by Molmil
NEDD4 HECT-Ub:Ub complex
分子名称: E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B
著者Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S.
登録日2012-09-27
公開日2013-05-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
3OLM
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BU of 3olm by Molmil
Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase
分子名称: E3 ubiquitin-protein ligase RSP5, Ubiquitin
著者Kim, H.C, Steffen, A, Chen, J, Huibregtse, J.M.
登録日2010-08-26
公開日2011-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献Structure and function of a HECT domain ubiquitin-binding site.
Embo Rep., 12, 2011
5TJ8
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BU of 5tj8 by Molmil
Structure of WWP2 WW2-2,3-linker-HECT (no WW2 observed)
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION
著者Chen, Z, Gabelli, S.B.
登録日2016-10-03
公開日2017-06-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
5TJ7
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BU of 5tj7 by Molmil
Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865
分子名称: CHLORIDE ION, NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION, ...
著者Chen, Z, Gabelli, S.B.
登録日2016-10-03
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017

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件を2024-05-15に公開中

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