5TJ7

Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865

Summary for 5TJ7

• Entry DOI: 10.2210/pdb5tj7/pdb
• Related: 5TJ8 5TJQ
• Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION, THIOCYANATE ION, ... (5 entities in total)
• Functional Keywords: wwp2, hect domain, ww2, wwp1, itch, autoinhibition, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O00308
• Total number of polymer chains: 4
• Total formula weight: 213928.66

Authors

Chen, Z.,Gabelli, S.B. (deposition date: 2016-10-03, release date: 2017-05-31, Last modification date: 2023-10-04)

• Primary citation: Chen, Z.,Jiang, H.,Xu, W.,Li, X.,Dempsey, D.R.,Zhang, X.,Devreotes, P.,Wolberger, C.,Amzel, L.M.,Gabelli, S.B.,Cole, P.A.; A Tunable Brake for HECT Ubiquitin Ligases.; Mol. Cell, 66:345-357.e6, 2017; PubMed: 28475870; DOI: 10.1016/j.molcel.2017.03.020

Experimental method

X-RAY DIFFRACTION (2.6 Å)