PDB: 126 件ウェブページステータス検索Chemie searchBIRD

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3QD6	Crystal structure of the CD40 and CD154 (CD40L) complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand, Tumor necrosis factor receptor superfamily member 5 著者 Lee, J.-O, Kim, Y.J, Song, D.H, Kim, H.M, Park, B.S. 登録日 2011-01-18 公開日 2011-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Crystallographic and mutational analysis of the CD40-CD154 complex and its implications for receptor activation J.Biol.Chem., 286, 2011
3LKJ	Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism 分子名称: (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand 著者 Silvian, L.F, Whitty, A. 登録日 2010-01-27 公開日 2011-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism. Acs Chem.Biol., 6, 2011
3MI8	The structure of TL1A-DCR3 COMPLEX 分子名称: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15, SECRETED FORM, Tumor necrosis factor receptor superfamily member 6B 著者 Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. 登録日 2010-04-09 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.951 Å) 主引用文献 Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011
3QBQ	Crystal structure of extracellular domains of mouse RANK-RANKL complex 分子名称: Tumor necrosis factor ligand superfamily member 11, Tumor necrosis factor receptor superfamily member 11A 著者 Ta, H.M, Nguyen, G.T.T, Jin, H.M, Choi, J.K, Park, H, Kim, N.S, Hwang, H.Y, Kim, K.K. 登録日 2011-01-13 公開日 2011-03-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-based development of a receptor activator of nuclear factor-kappaB ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis Proc.Natl.Acad.Sci.USA, 107, 2010
3V56	Re-refinement of PDB entry 1OSG - Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold - reveals an additonal copy of the peptide. 分子名称: BR3 derived peptive, SULFATE ION, Tumor necrosis factor ligand superfamily member 13B 著者 Smart, O.S, Womack, T.O, Flensburg, C, Keller, P, Sharff, A, Paciorek, W, Vonrhein, C, Bricogne, G. 登録日 2011-12-16 公開日 2012-03-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER. Acta Crystallogr.,Sect.D, 68, 2012
4EN0	Crystal structure of light 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, PHOSPHATE ION, ... 著者 Zhan, C, Liu, W, Patskovsky, Y, Ramagopal, U.A, Bonanno, J.B, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) 登録日 2012-04-12 公開日 2012-05-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
3URF	Human RANKL/OPG complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 11, soluble form, ... 著者 Wang, X.Q, Luan, X.D, Lu, Q.Y. 登録日 2011-11-22 公開日 2012-07-11 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin J.Immunol., 189, 2012
4E4D	Crystal structure of mouse RANKL-OPG complex 分子名称: CHLORIDE ION, Tumor necrosis factor ligand superfamily member 11, soluble form, ... 著者 Nelson, C.A, Fremont, D.H. 登録日 2012-03-12 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor. Structure, 20, 2012
4GIQ	Crystal Structure of mouse RANK bound to RANKL 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SODIUM ION, ... 著者 Nelson, C.A, Wang, M.W.-H, Fremont, D.H. 登録日 2012-08-08 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor. Structure, 20, 2012
4J6G	CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ... 著者 Liu, W, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-02-11 公開日 2013-03-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
4G3Y	Crystal structure of TNF-alpha in complex with Infliximab Fab fragment 分子名称: Tumor necrosis factor, infliximab Fab H, infliximab Fab L 著者 Liang, S.Y, Dai, J.X, Guo, Y.J, Lou, Z.Y. 登録日 2012-07-15 公開日 2013-03-27 最終更新日 2013-08-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for treating tumor necrosis factor alpha (TNFalpha)-associated diseases with the therapeutic antibody infliximab J.Biol.Chem., 288, 2013
4HT1	Human TWEAK in complex with the Fab fragment of a neutralizing antibody 分子名称: Tumor necrosis factor ligand superfamily member 12, chimeric antibody Fab 著者 Lammens, A. 登録日 2012-10-31 公開日 2013-06-12 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.498 Å) 主引用文献 Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. Plos One, 8, 2013
4KGQ	Crystal structure of a human light loop mutant in complex with dcr3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... 著者 Liu, W, Zhan, C, Bonanno, J.B, Sampathkumar, P, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) 登録日 2013-04-29 公開日 2013-07-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
4KG8	Crystal structure of light mutant 分子名称: Tumor necrosis factor ligand superfamily member 14 著者 Liu, W, Zhan, C, Kumar, P.R, Bonanno, J.B, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) 登録日 2013-04-28 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
4KGG	Crystal structure of light mutant2 and dcr3 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... 著者 Liu, W, Bonanno, J.B, Zhan, C, Kumar, P.R, Toro, R, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-04-29 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
3WD5	Crystal structure of TNFalpha in complex with Adalimumab Fab fragment 分子名称: Adalimumab Heavy Chain, Adalimumab Light Chain, Tumor necrosis factor 著者 Hu, S, Liang, S.Y, Guo, Y.J, Lou, Z.Y. 登録日 2013-06-06 公開日 2013-08-14 最終更新日 2015-07-01 実験手法 X-RAY DIFFRACTION (3.101 Å) 主引用文献 Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor alpha-associated diseases from a molecular view J.Biol.Chem., 288, 2013
4MXV	Structure of Lymphotoxin alpha bound to anti-LTa Fab 分子名称: Lymphotoxin-alpha, anti-Lymphotoxin alpha antibody heavy chain, anti-Lymphotoxin alpha antibody light chain 著者 Yin, J.P, Hymowitz, S.G. 登録日 2013-09-26 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
4MXW	Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab 分子名称: Lymphotoxin-alpha, Lymphotoxin-beta, Tumor necrosis factor receptor superfamily member 3, ... 著者 Sudhamsu, J, Yin, J.P, Hymowitz, S.G. 登録日 2013-09-26 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
4MSV	Crystal structure of FASL and DcR3 complex 分子名称: GLYCEROL, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 6, ... 著者 Liu, W, Ramagopal, U.A, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-09-18 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure, 24, 2016
4V46	Crystal structure of the BAFF-BAFF-R complex 分子名称: MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 13B, Tumor necrosis factor receptor superfamily member 13C 著者 Kim, H.M, Yu, K.S, Lee, M.E, Shin, D.R, Kim, Y.S, Paik, S.G, Yoo, O.J, Lee, H, Lee, J.-O. 登録日 2003-03-23 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation NAT.STRUCT.BIOL., 10, 2003
4N90	Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody 分子名称: Fab heavy chain, Fab light chain, Tumor necrosis factor ligand superfamily member 10, ... 著者 Huang, X. 登録日 2013-10-18 公開日 2014-09-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity. Cancer Cell, 26, 2014
4RSU	Crystal structure of the light and hvem complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... 著者 Liu, W, Ramagoal, U.A, Himmel, D, Bonanno, J.B, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2014-11-11 公開日 2015-02-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160. J.Exp.Med., 218, 2021
4TWT	Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21 分子名称: (2,4,6-trimethylbenzene-1,3,5-triyl)trimethanol, ALA-CYS-PRO-PRO-CYS-LEU-TRP-GLN-VAL-LEU-CYS-GLY, GLYCEROL, ... 著者 Luzi, S, Kondo, Y, Bernard, E, Stadler, L, Winter, G, Holliger, P. 登録日 2014-07-01 公開日 2015-02-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Subunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide. Protein Eng.Des.Sel., 28, 2015
4ZCH	Single-chain human APRIL-BAFF-BAFF Heterotrimer 分子名称: TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B 著者 Lammens, A, Jiang, X, Maskos, K, Schneider, P. 登録日 2015-04-16 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties. J.Biol.Chem., 290, 2015
5BNQ	Crystal structure of hRANKL-mRANK complex 分子名称: CHLORIDE ION, PHOSPHATE ION, SODIUM ION, ... 著者 Ren, J. 登録日 2015-05-26 公開日 2015-10-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis. Sci Rep, 5, 2015

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