3QBQ

Crystal structure of extracellular domains of mouse RANK-RANKL complex

Replaces:  3NZY

Summary for 3QBQ

• Entry DOI: 10.2210/pdb3qbq/pdb
• Descriptor: Tumor necrosis factor ligand superfamily member 11, Tumor necrosis factor receptor superfamily member 11A (3 entities in total)
• Functional Keywords: tumor necrosis factor (tnf) ligand-receptor superfamily fold, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• Biological source: Mus musculus (mouse); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Isoform 3: Cytoplasm. Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted: O35235; Membrane; Single-pass type I membrane protein (Potential): O35305
• Total number of polymer chains: 4
• Total formula weight: 73058.15

Authors

Ta, H.M.,Nguyen, G.T.T.,Jin, H.M.,Choi, J.K.,Park, H.,Kim, N.S.,Hwang, H.Y.,Kim, K.K. (deposition date: 2011-01-13, release date: 2011-03-02, Last modification date: 2023-11-01)

• Primary citation: Ta, H.M.,Nguyen, G.T.T.,Jin, H.M.,Choi, J.K.,Park, H.,Kim, N.S.,Hwang, H.Y.,Kim, K.K.; Structure-based development of a receptor activator of nuclear factor-kappaB ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis; Proc.Natl.Acad.Sci.USA, 107:20281-20286, 2010; PubMed: 21059944; DOI: 10.1073/pnas.1011686107

Experimental method

X-RAY DIFFRACTION (2.5 Å)