4KGQ

Crystal structure of a human light loop mutant in complex with dcr3

Summary for 4KGQ

Related4EN0 3K51 3MI8 3MHD 4J6G
DescriptorTumor necrosis factor receptor superfamily member 6B, Tumor necrosis factor ligand superfamily member 14, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordslight, dcr3, tnf, tnfr, tnf14, structural genomics, psi-biology, new hvem, n-glycosylation, membrane, secreted protein, cytokine, ifn, jelly-roll fold, bind tnf receptor hvem and ltbr, ltbr, protein structure initiative, atoms-to-animals: the immune function network, new york structural genomics research consortium, nysgrc, immune system
Biological sourceHomo sapiens (human)
Cellular locationTumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted. Isoform 2: Cytoplasm O95407
Secreted O43557
Total number of polymer chains4
Total molecular weight74091.34
Authors
Primary citation
Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C.
Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22:1252-1262, 2014
PubMed: 25087510 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2014.06.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.27 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.240506.2%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution