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4KGQ

Crystal structure of a human light loop mutant in complex with dcr3

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1C, DTumor necrosis factor receptor superfamily member 6Bpolymer17419044.22UniProt (O95407)
Pfam (PF00020)
In PDB
Homo sapiens (human)Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68
2A, BTumor necrosis factor ligand superfamily member 14polymer15817354.62UniProt (O43557)
Pfam (PF00229)
In PDB
Homo sapiens (human)Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form
3Ealpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched748.71In PDB
GlyTouCan (G81315DD)
4F2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
5C, DMAGNESIUM IONnon-polymer24.32Chemie (MG)
6waterwater18.0127Chemie (HOH)
Sequence modifications
C, D: 30 - 195 (UniProt: O95407)
PDBExternal DatabaseDetails
Thr 196-expression tag
Gly 197-expression tag
His 198-expression tag
His 199-expression tag
His 200-expression tag
His 201-expression tag
His 202-expression tag
His 203-expression tag
A, B: 83 - 240 (UniProt: O43557)
PDBExternal DatabaseDetails
Glu 214Lys 214variant
Asp 226Arg 226engineered mutation
Tyr 227Leu 227engineered mutation
Thr 228Arg 228engineered mutation
Lys 229Asp 229engineered mutation
Glu 230Gly 230engineered mutation
Asp 231Thr 231engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight72797.6
BranchedNumber of molecules2
Total formula weight1173.1
Non-Polymers*Number of molecules2
Total formula weight48.6
All*Total formula weight74019.3
*Water molecules are not included.

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PDB entries from 2024-09-18

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