4KGQ
Crystal structure of a human light loop mutant in complex with dcr3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C, D | Tumor necrosis factor receptor superfamily member 6B | polymer | 174 | 19044.2 | 2 | UniProt (O95407) Pfam (PF00020) In PDB | Homo sapiens (human) | Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68 |
2 | A, B | Tumor necrosis factor ligand superfamily member 14 | polymer | 158 | 17354.6 | 2 | UniProt (O43557) Pfam (PF00229) In PDB | Homo sapiens (human) | Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form |
3 | E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
4 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | C, D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
C, D: 30 - 195 (UniProt: O95407)
A, B: 83 - 240 (UniProt: O43557)
PDB | External Database | Details |
---|---|---|
Thr 196 | - | expression tag |
Gly 197 | - | expression tag |
His 198 | - | expression tag |
His 199 | - | expression tag |
His 200 | - | expression tag |
His 201 | - | expression tag |
His 202 | - | expression tag |
His 203 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Glu 214 | Lys 214 | variant |
Asp 226 | Arg 226 | engineered mutation |
Tyr 227 | Leu 227 | engineered mutation |
Thr 228 | Arg 228 | engineered mutation |
Lys 229 | Asp 229 | engineered mutation |
Glu 230 | Gly 230 | engineered mutation |
Asp 231 | Thr 231 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 72797.6 | |
Branched | Number of molecules | 2 |
Total formula weight | 1173.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 48.6 | |
All* | Total formula weight | 74019.3 |