4EN0

Crystal structure of light

Replaces:  3UGN

Summary for 4EN0

DescriptorTumor necrosis factor ligand superfamily member 14, PHOSPHATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywordsstructural genomics, psi-biology, new york structural genomics research consortium, nysgrc, immunity, tnf superfamily, hvem, dcr3, n-glycosylation, membrane, secreted protein, cytokine, atoms-to-animals: the immune function network, ifn, jelly-roll fold, bind tnf receptor hvem and ltbr, ltbr
Biological sourceHomo sapiens (human)
Cellular locationTumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted. Isoform 2: Cytoplasm O43557
Total number of polymer chains3
Total molecular weight55706.73
Authors
Primary citation
Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C.
Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22:1252-1262, 2014
PubMed: 25087510 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2014.06.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.59 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.287907.6%12.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution