4MXV

Structure of Lymphotoxin alpha bound to anti-LTa Fab

Summary for 4MXV

• Entry DOI: 10.2210/pdb4mxv/pdb
• Related: 1TNR 4MXW
• Descriptor: Lymphotoxin-alpha, anti-Lymphotoxin alpha antibody light chain, anti-Lymphotoxin alpha antibody heavy chain (3 entities in total)
• Functional Keywords: tnf, tumor necrosis factor, tnfr receptor, lymphotoxin beta receptor, lymphotoxin alpha, lymphoid development, tumor immunity, auto-immunity, cytokine-immune system complex, cytokine/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01374
• Total number of polymer chains: 9
• Total formula weight: 189808.78

Authors

Yin, J.P.,Hymowitz, S.G. (deposition date: 2013-09-26, release date: 2013-11-13, Last modification date: 2023-09-20)

• Primary citation: Sudhamsu, J.,Yin, J.,Chiang, E.Y.,Starovasnik, M.A.,Grogan, J.L.,Hymowitz, S.G.; Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction.; Proc.Natl.Acad.Sci.USA, 110:19896-19901, 2013; PubMed: 24248355; DOI: 10.1073/pnas.1310838110

Experimental method

X-RAY DIFFRACTION (3.2 Å)