4MXW

Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab

Summary for 4MXW

• Entry DOI: 10.2210/pdb4mxw/pdb
• Related: 4MXV
• Descriptor: Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-alpha, Lymphotoxin-beta, ... (5 entities in total)
• Functional Keywords: tnf, tumor necrosis factor, tnfr receptor, lymphotoxin beta receptor, lymphotoxin alpha, lymphoid development, tumor immunity, auto-immunity, cytokine-immune system complex, cytokine/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P36941; Secreted: P01374; Membrane; Single-pass type II membrane protein (Potential): Q06643
• Total number of polymer chains: 12
• Total formula weight: 259331.18

Authors

Sudhamsu, J.,Yin, J.P.,Hymowitz, S.G. (deposition date: 2013-09-26, release date: 2013-11-13, Last modification date: 2023-09-20)

• Primary citation: Sudhamsu, J.,Yin, J.,Chiang, E.Y.,Starovasnik, M.A.,Grogan, J.L.,Hymowitz, S.G.; Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction.; Proc.Natl.Acad.Sci.USA, 110:19896-19901, 2013; PubMed: 24248355; DOI: 10.1073/pnas.1310838110

Experimental method

X-RAY DIFFRACTION (3.6 Å)