4MXW

Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
D	0005164	molecular_function	tumor necrosis factor receptor binding
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0006915	biological_process	apoptotic process
R	0006955	biological_process	immune response
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0048534	biological_process	hematopoietic or lymphoid organ development
S	0004888	molecular_function	transmembrane signaling receptor activity
S	0006915	biological_process	apoptotic process
S	0006955	biological_process	immune response
S	0007165	biological_process	signal transduction
S	0016020	cellular_component	membrane
S	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
S	0048534	biological_process	hematopoietic or lymphoid organ development
X	0005164	molecular_function	tumor necrosis factor receptor binding
X	0006955	biological_process	immune response
X	0016020	cellular_component	membrane
Y	0005164	molecular_function	tumor necrosis factor receptor binding
Y	0006955	biological_process	immune response
Y	0016020	cellular_component	membrane
Z	0005164	molecular_function	tumor necrosis factor receptor binding
Z	0006955	biological_process	immune response
Z	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LlVPtSGIYFVysQVvF

Chain	Residue	Details
X	LEU99-PHE115
Y	LEU125-TYR141

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
W	TYR193-HIS199
V	TYR192-HIS198

---

site_id	PS00652
Number of Residues	38
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. CrdqekeYyepqhri...C..Csr.Cppgtyvsak..Csrir..DTVC

Chain	Residue	Details
S	CYS43-CYS80
S	CYS83-CYS126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Repeat: {"description":"TNFR-Cys 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000048","evidences":[{"source":"PubMed","id":"1451807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---