4MXW

Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, H (S, R)	Tumor necrosis factor receptor superfamily member 3	polymer	193	21367.1	2	UniProt (P36941) Pfam (PF00020)	Homo sapiens (human)	Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor type III, TNF-RIII, TNFR-III
2	B, E (X, A)	Lymphotoxin-alpha	polymer	157	17313.3	2	UniProt (P01374) Pfam (PF00229)	Homo sapiens (human)	LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1
3	C, D, F, G (Y, Z, B, D)	Lymphotoxin-beta	polymer	210	22514.5	4	UniProt (Q06643) Pfam (PF00229)	Homo sapiens (human)	LT-beta, Tumor necrosis factor C, TNF-C, Tumor necrosis factor ligand superfamily member 3
4	I, J (W, H)	anti-Lymphotoxin alpha antibody heavy chain	polymer	213	22890.7	2		Homo sapiens (human)	anti-LT-alpha antibody heavy chain
5	K, L (V, L)	anti-Lymphotoxin alpha antibody light chain	polymer	211	23065.5	2		Homo sapiens (human)	anti-LT-alpha antibody light chain

Sequence modifications

S, R: 41 - 211 (UniProt: P36941)

PDB	External Database	Details
Ala 19	-	expression tag
Asp 20	-	expression tag
Leu 21	-	expression tag
Gly 22	-	expression tag
Ser 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
His 28	-	expression tag
His 29	-	expression tag
Ser 30	-	expression tag
Ser 31	-	expression tag
Gly 32	-	expression tag
Leu 33	-	expression tag
Val 34	-	expression tag
Pro 35	-	expression tag
Arg 36	-	expression tag
Gly 37	-	expression tag
Ser 38	-	expression tag
His 39	-	expression tag
Met 40	-	expression tag

X, A: 62 - 205 (UniProt: P01374)

PDB	External Database	Details
Ala 49	-	expression tag
Asp 50	-	expression tag
Leu 51	-	expression tag
Gly 52	-	expression tag
Ser 53	-	expression tag
Asp 54	-	expression tag
Tyr 55	-	expression tag
Lys 56	-	expression tag
Asp 57	-	expression tag
Asp 58	-	expression tag
Asp 59	-	expression tag
Asp 60	-	expression tag
Lys 61	-	expression tag

Y, Z, B, D: 86 - 244 (UniProt: Q06643)

PDB	External Database	Details
Met 43	-	expression tag
Leu 44	-	expression tag
Leu 45	-	expression tag
Val 46	-	expression tag
Asn 47	-	expression tag
Gln 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
Gln 51	-	expression tag
Gly 52	-	expression tag
Phe 53	-	expression tag
Asn 54	-	expression tag
Lys 55	-	expression tag
Glu 56	-	expression tag
His 57	-	expression tag
Thr 58	-	expression tag
Ser 59	-	expression tag
Lys 60	-	expression tag
Met 61	-	expression tag
Val 62	-	expression tag
Ser 63	-	expression tag
Ala 64	-	expression tag
Ile 65	-	expression tag
Val 66	-	expression tag
Leu 67	-	expression tag
Tyr 68	-	expression tag
Val 69	-	expression tag
Leu 70	-	expression tag
Leu 71	-	expression tag
Ala 72	-	expression tag
Ala 73	-	expression tag
Ala 74	-	expression tag
Ala 75	-	expression tag
His 76	-	expression tag
Ser 77	-	expression tag
Ala 78	-	expression tag
Phe 79	-	expression tag
Ala 80	-	expression tag
Ala 81	-	expression tag
Asp 82	-	expression tag
Leu 83	-	expression tag
Gly 84	-	expression tag
Ser 85	-	expression tag
His 245	-	expression tag
His 246	-	expression tag
His 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	259331.2
All*	Total formula weight	259331.2

*Water molecules are not included.