4TWT

Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21

Summary for 4TWT

Entry DOI	10.2210/pdb4twt/pdb
Descriptor	Tumor necrosis factor, ALA-CYS-PRO-PRO-CYS-LEU-TRP-GLN-VAL-LEU-CYS-GLY, GLYCEROL, ... (5 entities in total)
Functional Keywords	tumor necrosis factor-alpha, bicyclo compounds, peptides, cytokine-inhibitor complex, cytokine/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375
Total number of polymer chains	6
Total formula weight	73034.91
Authors	Luzi, S.,Kondo, Y.,Bernard, E.,Stadler, L.,Winter, G.,Holliger, P. (deposition date: 2014-07-01, release date: 2015-02-04, Last modification date: 2023-12-20)
Primary citation	Luzi, S.,Kondo, Y.,Bernard, E.,Stadler, L.K.,Vaysburd, M.,Winter, G.,Holliger, P. Subunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide. Protein Eng.Des.Sel., 28:45-52, 2015 Cited by PubMed: 25614525 DOI: 10.1093/protein/gzu055 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation