4TWT
Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E, F (A, B, C, D) | Tumor necrosis factor | polymer | 157 | 17370.7 | 4 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (Human) | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a |
| 2 | C, D (E, F) | ALA-CYS-PRO-PRO-CYS-LEU-TRP-GLN-VAL-LEU-CYS-GLY | polymer | 12 | 1289.6 | 2 | synthetic construct | peptide M21 | |
| 3 | G, H, I, J, M... (B, E, C, D) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 4 | K, L (E, F) | (2,4,6-trimethylbenzene-1,3,5-triyl)trimethanol | non-polymer | 210.3 | 2 | Chemie (38A) | |||
| 5 | O, P, Q, R, S... (A, B, E, F, C...) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 72061.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 973.1 | |
| All* | Total formula weight | 73034.9 |
