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4TWT

Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
D0005164molecular_functiontumor necrosis factor receptor binding
D0006955biological_processimmune response
D0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue GOL B 201
ChainResidue
ATYR119
BPRO117
BILE118
BTYR119

site_idAC2
Number of Residues5
Detailsbinding site for residue GOL B 202
ChainResidue
BLEU26
BALA134
BGLU135
BILE136
BPRO139

site_idAC3
Number of Residues4
Detailsbinding site for residue GOL E 101
ChainResidue
AARG138
ATYR141
EALA1
ECYS2

site_idAC4
Number of Residues1
Detailsbinding site for residue GOL E 102
ChainResidue
EGLY12

site_idAC5
Number of Residues1
Detailsbinding site for residue GOL C 201
ChainResidue
CPRO51

site_idAC6
Number of Residues4
Detailsbinding site for residue GOL D 201
ChainResidue
CPRO117
CILE118
CTYR119
DTYR119

site_idAC7
Number of Residues13
Detailsbinding site for peptide chain E
ChainResidue
ALEU57
ATYR119
AARG138
ATYR141
ALEU157
BHIS15
BLEU57
BTYR59
BLEU120
BGLY148
BGLN149
BTYR151
CTYR87

site_idAC8
Number of Residues9
Detailsbinding site for peptide chain F
ChainResidue
CTYR119
CLEU157
DHIS15
DLEU57
DTYR59
DSER147
DGLY148
DGLN149
DTYR151

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000269|PubMed:8631363
ChainResidueDetails
ASER4
BSER4
CSER4
DSER4

224931

PDB entries from 2024-09-11

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