4G3Y

Crystal structure of TNF-alpha in complex with Infliximab Fab fragment

Summary for 4G3Y

• Entry DOI: 10.2210/pdb4g3y/pdb
• Related: 4G3Z
• Descriptor: infliximab Fab L, infliximab Fab H, Tumor necrosis factor, ... (4 entities in total)
• Functional Keywords: tnf, infliximab, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375
• Total number of polymer chains: 3
• Total formula weight: 65187.71

Authors

Liang, S.Y.,Dai, J.X.,Guo, Y.J.,Lou, Z.Y. (deposition date: 2012-07-15, release date: 2013-03-27, Last modification date: 2024-10-30)

Primary citation

Liang, S.Y.,Dai, J.X.,Hou, S.,Su, L.,Zhang, D.,Guo, H.,Hu, S.,Wang, H.,Rao, Z.,Guo, Y.J.,Lou, Z.Y.
Structural basis for treating tumor necrosis factor alpha (TNFalpha)-associated diseases with the therapeutic antibody infliximab
J.Biol.Chem., 288:13799-13807, 2013

PubMed Abstract: Although infliximab has high efficacy in treating TNFα-associated diseases, the epitope on TNFα remains unclear.

PubMed: 23504311
DOI: 10.1074/jbc.M112.433961

Experimental method

X-RAY DIFFRACTION (2.6 Å)