4HT1
Human TWEAK in complex with the Fab fragment of a neutralizing antibody
Summary for 4HT1
Entry DOI | 10.2210/pdb4ht1/pdb |
Descriptor | Tumor necrosis factor ligand superfamily member 12, chimeric antibody Fab, ... (4 entities in total) |
Functional Keywords | antibody fab, tnf homology domain, cytokine, tweak receptor, membrane bound, extracellular thd domain, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted. Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein: O43508 |
Total number of polymer chains | 3 |
Total formula weight | 64801.81 |
Authors | Lammens, A. (deposition date: 2012-10-31, release date: 2013-06-12, Last modification date: 2017-11-15) |
Primary citation | Lammens, A.,Baehner, M.,Kohnert, U.,Niewoehner, J.,von Proff, L.,Schraeml, M.,Lammens, K.,Hopfner, K.P. Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. Plos One, 8:e62697-e62697, 2013 Cited by PubMed: 23667509DOI: 10.1371/journal.pone.0062697 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.498 Å) |
Structure validation
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