PDB: 255 件ウェブページステータス検索Chemie searchBIRD

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6HGE	Crystal structure of Alpha1-antichymotrypsin variant NewBG-I in the uncleaved S-conformation 分子名称: Alpha-1-antichymotrypsin 著者 Gardill, B.R, Schmidt, K, Muller, Y.A. 登録日 2018-08-23 公開日 2019-05-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy. J.Struct.Biol., 207, 2019
6I7U	Alpha-1-antitrypsin (Ala250Met) in the native conformation 分子名称: Alpha-1-antitrypsin 著者 Aldobiyan, I, Lomas, D.A, Irving, J.A. 登録日 2018-11-19 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural determinants of instability in alpha-1-antitrypsin To Be Published
6I3I	Crystal structure of reactive center loop (RCL) cleaved angiotensinogen 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen 著者 Yan, Y, Read, R.J. 登録日 2018-11-06 公開日 2018-12-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
6I8S	Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 分子名称: HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, Plasminogen activator inhibitor 1 著者 Vousden, K.A, Lundqvist, T, Popovic, B. 登録日 2018-11-21 公開日 2019-02-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1. Sci Rep, 9, 2019
6I4V	Alpha-1-antitrypsin Queen's (K154N) variant 分子名称: 3-trimethylsilylpropane-1-sulfonic acid, Alpha-1-antitrypsin, GLYCINE 著者 Aldobiyan, I, Lomas, D.A, Irving, J.A. 登録日 2018-11-12 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural determinants of instability in alpha-1-antitrypsin To Be Published
6IAY	Alpha-1-antitrypsin Queen's (Lys154Asn) variant 分子名称: Alpha-1-antitrypsin, GLYCINE 著者 Aldobiyan, I, Lomas, D.A, Irving, J.A. 登録日 2018-11-28 公開日 2019-12-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural determinants of instability in alpha-1-antitrypsin To Be Published
6I3Z	Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen 分子名称: Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ... 著者 Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Fra, A, Lomas, D.A, Irving, J.A. 登録日 2018-11-08 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5, 2020
5ZLZ	Structure of tPA and PAI-1 分子名称: GLYCEROL, Plasminogen activator inhibitor 1, Tissue-type plasminogen activator 著者 Min, L, Huang, M. 登録日 2018-03-31 公開日 2019-04-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.581 Å) 主引用文献 Development of a PAI-1 trapping agent (PAItrap2) based on inactivated tPA-SPD and the crystal structure of PAItrap2 in complex with PAI-1 To Be Published
7BEE	Crystal structure of a Hsp47-collagen peptide complex 分子名称: 21er collagen model peptide, Collagen-binding protein 著者 Abraham, E.T, Gebauer, J.M, Baumann, U. 登録日 2020-12-23 公開日 2021-11-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.939 Å) 主引用文献 Collagen's primary structure determines collagen:HSP47 complex stoichiometry. J.Biol.Chem., 297, 2021
7BDU	Crystal structure of a Hsp47-collagen peptide complex 分子名称: 21er collagen model peptide, Collagen-binding protein 著者 Abraham, E.T, Gebauer, J.M, Baumann, U. 登録日 2020-12-22 公開日 2021-11-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Collagen's primary structure determines collagen:HSP47 complex stoichiometry. J.Biol.Chem., 297, 2021
5BRR	Michaelis complex of tPA-S195A:PAI-1 分子名称: GLYCEROL, Plasminogen activator inhibitor 1, TRIETHYLENE GLYCOL, ... 著者 Gong, L. 登録日 2015-06-01 公開日 2015-09-02 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1 J.Biol.Chem., 290, 2015
3B9F	1.6 A structure of the PCI-thrombin-heparin complex 分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, GLYCEROL, Plasma serine protease inhibitor, ... 著者 Li, W, Adams, T.E, Huntington, J.A. 登録日 2007-11-05 公開日 2008-04-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. Proc.Natl.Acad.Sci.Usa, 105, 2008
4DY7	Crystal structures of protease nexin-1 in complex with S195A thrombin 分子名称: ACETATE ION, CALCIUM ION, Glia-derived nexin, ... 著者 Huntington, J.A, Li, W. 登録日 2012-02-28 公開日 2012-08-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism. Blood, 120, 2012
7AKV	The cryo-EM structure of the Vag8-C1 inhibitor complex 分子名称: Plasma protease C1 inhibitor, Vag8 著者 Johnson, S, Lea, S.M, Deme, J.C, Furlong, E, Dhillon, A. 登録日 2020-10-02 公開日 2021-06-16 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex. Mbio, 12, 2021
3KCG	Crystal structure of the antithrombin-factor IXa-pentasaccharide complex 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, Antithrombin-III, ... 著者 Huntington, J.A, Johnson, D.J.D. 登録日 2009-10-21 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex. Proc.Natl.Acad.Sci.USA, 107, 2010
2D26	Active site distortion is sufficient for proteinase inhibit second crystal structure of covalent serpin-proteinase complex 分子名称: Alpha-1-antitrypsin, Elastase-1 著者 Dementiev, A, Dobo, J, Gettins, P.G. 登録日 2005-09-03 公開日 2005-11-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Active Site Distortion Is Sufficient for Proteinase Inhibition by Serpins: Structure of the covalent complex of alpha 1-proteinase inhibitor with porcine pancreatic elastase J.Biol.Chem., 281, 2006
2GD4	Crystal Structure of the Antithrombin-S195A Factor Xa-Pentasaccharide Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ... 著者 Johnson, D.J, Li, W, Adams, T.E, Huntington, J.A. 登録日 2006-03-15 公開日 2006-05-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. Embo J., 25, 2006
3PB1	Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator 分子名称: Plasminogen activator inhibitor 1, Plasminogen activator, urokinase, ... 著者 Lin, Z, Jiang, L, Huang, M, Structure 2 Function Project (S2F) 登録日 2010-10-20 公開日 2010-12-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J.Biol.Chem., 286, 2011
1SR5	ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE 分子名称: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-2,3,6-tri-O-methyl-alpha-D-xylo-hexopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3R,4S,5S,6S)-6-(dihydroxymethyl)-3,4-dimethoxytetrahydro-2H-pyran-2,5-diol-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3R,4S,5S,6R)-6-(dihydroxymethyl)-3,4-dimethoxytetrahydro-2H-pyran-2,5-diol-(1-4)-1,5-anhydro-3-O-methyl-2,6-di-O-sulfo-D-glucitol, ... 著者 Dementiev, A, Petitou, M, Gettins, P.G. 登録日 2004-03-22 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity. Nat.Struct.Mol.Biol., 11, 2004
1TB6	2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Li, W, Johnson, D.J, Esmon, C.T, Huntington, J.A. 登録日 2004-05-19 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat.Struct.Mol.Biol., 11, 2004
3F1S	Crystal structure of Protein Z complexed with protein Z-dependent inhibitor 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Zhou, A. 登録日 2008-10-28 公開日 2009-06-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. Blood, 2009
1OC0	plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin 分子名称: PLASMINOGEN ACTIVATOR INHIBITOR-1, VITRONECTIN 著者 Read, R.J, Zhou, A, Huntington, J.A, Pannu, N.S, Carrell, R.W. 登録日 2003-02-03 公開日 2003-06-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 How Vitronectin Binds Pai-1 to Modulate Fibrinolysis and Cell Migration Nat.Struct.Biol., 10, 2003
1OPH	NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN 分子名称: Alpha-1-antitrypsin precursor, Trypsinogen, cationic precursor 著者 Dementiev, A, Simonovic, M, Volz, K, Gettins, P.G. 登録日 2003-03-05 公開日 2003-08-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases J.Biol.Chem., 278, 2003
2B5T	2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules 分子名称: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Johnson, D.J, Li, W, Luis, S.A, Carrell, R.W, Huntington, J.A. 登録日 2005-09-29 公開日 2006-09-19 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation. J.Biol.Chem., 281, 2006
1EZX	CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX 分子名称: ALPHA-1-ANTITRYPSIN, TRYPSIN 著者 Huntington, J.A, Carrell, R.W. 登録日 2000-05-12 公開日 2000-10-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of a serpin-protease complex shows inhibition by deformation. Nature, 407, 2000

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