3KCG
Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
Summary for 3KCG
Entry DOI | 10.2210/pdb3kcg/pdb |
Related PRD ID | PRD_900031 |
Descriptor | Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, Antithrombin-III, ... (9 entities in total) |
Functional Keywords | michaelis complex, blood coagulation, calcium, disulfide bond, egf-like domain, glycoprotein, hemophilia, hydrolase, pharmaceutical, protease, secreted, serine protease, sulfation, zymogen, heparin-binding, protease inhibitor, serine protease inhibitor, thrombophilia, hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 84989.27 |
Authors | Huntington, J.A.,Johnson, D.J.D. (deposition date: 2009-10-21, release date: 2010-02-02, Last modification date: 2023-11-01) |
Primary citation | Johnson, D.J.,Langdown, J.,Huntington, J.A. Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex. Proc.Natl.Acad.Sci.USA, 107:645-650, 2010 Cited by PubMed: 20080729DOI: 10.1073/pnas.0910144107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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