4DY7

Crystal structures of protease nexin-1 in complex with S195A thrombin

Summary for 4DY7

• Entry DOI: 10.2210/pdb4dy7/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, Glia-derived nexin, ... (7 entities in total)
• Functional Keywords: serpin, protease, heparin, cell surface, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734 P07093
• Total number of polymer chains: 6
• Total formula weight: 154922.04

Authors

Huntington, J.A.,Li, W. (deposition date: 2012-02-28, release date: 2012-08-15)

• Primary citation: Li, W.,Huntington, J.A.; Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.; Blood, 120:459-467, 2012; PubMed: 22618708; DOI: 10.1182/blood-2012-03-415869

Experimental method

X-RAY DIFFRACTION (2.8 Å)