4DY7

Crystal structures of protease nexin-1 in complex with S195A thrombin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0007596	biological_process	blood coagulation
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005509	molecular_function	calcium ion binding
B	0006508	biological_process	proteolysis
B	0007596	biological_process	blood coagulation
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005539	molecular_function	glycosaminoglycan binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0007399	biological_process	nervous system development
C	0008201	molecular_function	heparin binding
C	0010544	biological_process	negative regulation of platelet activation
C	0010757	biological_process	negative regulation of plasminogen activation
C	0010955	biological_process	negative regulation of protein processing
C	0030154	biological_process	cell differentiation
C	0030195	biological_process	negative regulation of blood coagulation
C	0030334	biological_process	regulation of cell migration
C	0030414	molecular_function	peptidase inhibitor activity
C	0031012	cellular_component	extracellular matrix
C	0031091	cellular_component	platelet alpha granule
C	0031594	cellular_component	neuromuscular junction
C	0045861	biological_process	negative regulation of proteolysis
C	0048711	biological_process	positive regulation of astrocyte differentiation
C	0090331	biological_process	negative regulation of platelet aggregation
C	1903561	cellular_component	extracellular vesicle
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0007596	biological_process	blood coagulation
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005509	molecular_function	calcium ion binding
E	0006508	biological_process	proteolysis
E	0007596	biological_process	blood coagulation
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0005102	molecular_function	signaling receptor binding
F	0005515	molecular_function	protein binding
F	0005539	molecular_function	glycosaminoglycan binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005829	cellular_component	cytosol
F	0007399	biological_process	nervous system development
F	0008201	molecular_function	heparin binding
F	0010544	biological_process	negative regulation of platelet activation
F	0010757	biological_process	negative regulation of plasminogen activation
F	0010955	biological_process	negative regulation of protein processing
F	0030154	biological_process	cell differentiation
F	0030195	biological_process	negative regulation of blood coagulation
F	0030334	biological_process	regulation of cell migration
F	0030414	molecular_function	peptidase inhibitor activity
F	0031012	cellular_component	extracellular matrix
F	0031091	cellular_component	platelet alpha granule
F	0031594	cellular_component	neuromuscular junction
F	0045861	biological_process	negative regulation of proteolysis
F	0048711	biological_process	positive regulation of astrocyte differentiation
F	0090331	biological_process	negative regulation of platelet aggregation
F	1903561	cellular_component	extracellular vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 101

Chain	Residue
A	SER14
A	TYR14
A	ILE14
A	ASP14
A	GLY14
A	ARG15
A	CA102
F	LYS75

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 102

Chain	Residue
A	ASP14
A	ARG15
A	ACT101
B	GLY133
A	SER14

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT B 301

Chain	Residue
B	VAL163
B	PHE181

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 302

Chain	Residue
B	ASP221
B	ARG221
B	LYS224

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 401

Chain	Residue
C	ASN221
C	TRP351
C	PHE352
C	ILE353

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 401

Chain	Residue
F	ALA306
F	THR309
F	GLY311

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
B	LEU53-CYS58

---

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FIVDRPFLFfI

Chain	Residue	Details
C	PHE352-ILE362

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Reactive bond","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---