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4DY7

Crystal structures of protease nexin-1 in complex with S195A thrombin

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0006508biological_processproteolysis
A0007596biological_processblood coagulation
B0004252molecular_functionserine-type endopeptidase activity
B0005509molecular_functioncalcium ion binding
B0006508biological_processproteolysis
B0007596biological_processblood coagulation
C0004867molecular_functionserine-type endopeptidase inhibitor activity
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005539molecular_functionglycosaminoglycan binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005829cellular_componentcytosol
C0007399biological_processnervous system development
C0007596biological_processblood coagulation
C0008201molecular_functionheparin binding
C0008285biological_processnegative regulation of cell population proliferation
C0009611biological_processresponse to wounding
C0010544biological_processnegative regulation of platelet activation
C0010757biological_processnegative regulation of plasminogen activation
C0010766biological_processnegative regulation of sodium ion transport
C0010955biological_processnegative regulation of protein processing
C0021683biological_processcerebellar granular layer morphogenesis
C0030154biological_processcell differentiation
C0030163biological_processprotein catabolic process
C0030168biological_processplatelet activation
C0030195biological_processnegative regulation of blood coagulation
C0030308biological_processnegative regulation of cell growth
C0030334biological_processregulation of cell migration
C0031091cellular_componentplatelet alpha granule
C0031594cellular_componentneuromuscular junction
C0032940biological_processsecretion by cell
C0033363biological_processsecretory granule organization
C0042177biological_processnegative regulation of protein catabolic process
C0042628biological_processmating plug formation
C0045861biological_processnegative regulation of proteolysis
C0045879biological_processnegative regulation of smoothened signaling pathway
C0048505biological_processregulation of timing of cell differentiation
C0048711biological_processpositive regulation of astrocyte differentiation
C0050974biological_processdetection of mechanical stimulus involved in sensory perception
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051966biological_processregulation of synaptic transmission, glutamatergic
C0060291biological_processlong-term synaptic potentiation
C0060384biological_processinnervation
C0061108biological_processseminal vesicle epithelium development
C0062023cellular_componentcollagen-containing extracellular matrix
C0090331biological_processnegative regulation of platelet aggregation
C1903561cellular_componentextracellular vesicle
D0004252molecular_functionserine-type endopeptidase activity
D0005576cellular_componentextracellular region
D0006508biological_processproteolysis
D0007596biological_processblood coagulation
E0004252molecular_functionserine-type endopeptidase activity
E0005509molecular_functioncalcium ion binding
E0006508biological_processproteolysis
E0007596biological_processblood coagulation
F0004867molecular_functionserine-type endopeptidase inhibitor activity
F0005102molecular_functionsignaling receptor binding
F0005515molecular_functionprotein binding
F0005539molecular_functionglycosaminoglycan binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005829cellular_componentcytosol
F0007399biological_processnervous system development
F0007596biological_processblood coagulation
F0008201molecular_functionheparin binding
F0008285biological_processnegative regulation of cell population proliferation
F0009611biological_processresponse to wounding
F0010544biological_processnegative regulation of platelet activation
F0010757biological_processnegative regulation of plasminogen activation
F0010766biological_processnegative regulation of sodium ion transport
F0010955biological_processnegative regulation of protein processing
F0021683biological_processcerebellar granular layer morphogenesis
F0030154biological_processcell differentiation
F0030163biological_processprotein catabolic process
F0030168biological_processplatelet activation
F0030195biological_processnegative regulation of blood coagulation
F0030308biological_processnegative regulation of cell growth
F0030334biological_processregulation of cell migration
F0031091cellular_componentplatelet alpha granule
F0031594cellular_componentneuromuscular junction
F0032940biological_processsecretion by cell
F0033363biological_processsecretory granule organization
F0042177biological_processnegative regulation of protein catabolic process
F0042628biological_processmating plug formation
F0045861biological_processnegative regulation of proteolysis
F0045879biological_processnegative regulation of smoothened signaling pathway
F0048505biological_processregulation of timing of cell differentiation
F0048711biological_processpositive regulation of astrocyte differentiation
F0050974biological_processdetection of mechanical stimulus involved in sensory perception
F0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0051966biological_processregulation of synaptic transmission, glutamatergic
F0060291biological_processlong-term synaptic potentiation
F0060384biological_processinnervation
F0061108biological_processseminal vesicle epithelium development
F0062023cellular_componentcollagen-containing extracellular matrix
F0090331biological_processnegative regulation of platelet aggregation
F1903561cellular_componentextracellular vesicle
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT A 101
ChainResidue
ASER14
ATYR14
AILE14
AASP14
AGLY14
AARG15
ACA102
FLYS75

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 102
ChainResidue
AASP14
AARG15
AACT101
BGLY133
ASER14

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ACT B 301
ChainResidue
BVAL163
BPHE181

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE NA B 302
ChainResidue
BASP221
BARG221
BLYS224

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT C 401
ChainResidue
CASN221
CTRP351
CPHE352
CILE353

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA F 401
ChainResidue
FALA306
FTHR309
FGLY311

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
BLEU53-CYS58

site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. FIVDRPFLFfI
ChainResidueDetails
CPHE352-ILE362

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Reactive bond => ECO:0000255
ChainResidueDetails
CARG346
FARG346
BALA195
EHIS57
EASP102
EALA195

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN99
CASN140
FASN99
FASN140

222415

PDB entries from 2024-07-10

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