4DY7
Crystal structures of protease nexin-1 in complex with S195A thrombin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Thrombin light chain | polymer | 49 | 5641.2 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B, E (B, E) | Thrombin heavy chain | polymer | 259 | 29764.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C, F (C, F) | Glia-derived nexin | polymer | 379 | 41915.5 | 2 | UniProt (P07093) Pfam (PF00079) | Homo sapiens (human) | GDN, Peptidase inhibitor 7, PI-7, Protease nexin 1, PN-1, Protease nexin I, Serpin E2 |
| 4 | G, I, K (A, B, C) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | H, L (A, F) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | J (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
B, E: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 154641.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 280.3 | |
| All* | Total formula weight | 154922.0 |
