6I3Z
Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen
Summary for 6I3Z
Entry DOI | 10.2210/pdb6i3z/pdb |
Related | 6IO1 |
Descriptor | Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ... (7 entities in total) |
Functional Keywords | antibody fragment, antitrypsin binding, diagnostic, monoclonal, protein binding, selective, wild-type, glu342, e342 |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 91886.18 |
Authors | Laffranchi, M.,Elliston, E.L.K.,Miranda, E.,Perez, J.,Jagger, A.M.,Fra, A.,Lomas, D.A.,Irving, J.A. (deposition date: 2018-11-08, release date: 2019-11-20, Last modification date: 2024-01-24) |
Primary citation | Laffranchi, M.,Elliston, E.L.,Miranda, E.,Perez, J.,Ronzoni, R.,Jagger, A.M.,Heyer-Chauhan, N.,Brantly, M.L.,Fra, A.,Lomas, D.A.,Irving, J.A. Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5:-, 2020 Cited by PubMed: 32699193DOI: 10.1172/jci.insight.135459 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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