6I8S

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1

Summary for 6I8S

• Entry DOI: 10.2210/pdb6i8s/pdb
• Descriptor: Plasminogen activator inhibitor 1, HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, ... (4 entities in total)
• Functional Keywords: serpin, plasminogen activator inhibitor-1, pai-1, antibody, fab, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 359762.65

Authors

Vousden, K.A.,Lundqvist, T.,Popovic, B. (deposition date: 2018-11-21, release date: 2019-02-13, Last modification date: 2024-01-24)

• Primary citation: Vousden, K.A.,Lundqvist, T.,Popovic, B.,Naiman, B.,Carruthers, A.M.,Newton, P.,Johnson, D.J.D.,Pomowski, A.,Wilkinson, T.,Dufner, P.,de Mendez, I.,Mallinder, P.R.,Murray, C.,Strain, M.,Connor, J.,Murray, L.A.,Sleeman, M.A.,Lowe, D.C.,Huntington, J.A.,Vaughan, T.J.; Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.; Sci Rep, 9:1605-1605, 2019; PubMed: 30733557; DOI: 10.1038/s41598-019-38842-x

Experimental method

X-RAY DIFFRACTION (2.9 Å)