6I8S
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
Summary for 6I8S
Entry DOI | 10.2210/pdb6i8s/pdb |
Descriptor | Plasminogen activator inhibitor 1, HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, ... (4 entities in total) |
Functional Keywords | serpin, plasminogen activator inhibitor-1, pai-1, antibody, fab, blood clotting |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 359762.65 |
Authors | Vousden, K.A.,Lundqvist, T.,Popovic, B. (deposition date: 2018-11-21, release date: 2019-02-13, Last modification date: 2024-01-24) |
Primary citation | Vousden, K.A.,Lundqvist, T.,Popovic, B.,Naiman, B.,Carruthers, A.M.,Newton, P.,Johnson, D.J.D.,Pomowski, A.,Wilkinson, T.,Dufner, P.,de Mendez, I.,Mallinder, P.R.,Murray, C.,Strain, M.,Connor, J.,Murray, L.A.,Sleeman, M.A.,Lowe, D.C.,Huntington, J.A.,Vaughan, T.J. Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1. Sci Rep, 9:1605-1605, 2019 Cited by PubMed: 30733557DOI: 10.1038/s41598-019-38842-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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