5BRR

Michaelis complex of tPA-S195A:PAI-1

Summary for 5BRR

Entry DOI	10.2210/pdb5brr/pdb
Descriptor	Plasminogen activator inhibitor 1, Tissue-type plasminogen activator, GLYCEROL, ... (5 entities in total)
Functional Keywords	tissue-type plasminogen activator catalytic domain, plasminogen activator inhibitor 1, structure-activity relationship, thrombolysis, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P05121 Secreted, extracellular space: P00750
Total number of polymer chains	2
Total formula weight	71424.42
Authors	Gong, L. (deposition date: 2015-06-01, release date: 2015-09-02, Last modification date: 2017-10-18)
Primary citation	Gong, L.,Liu, M.,Zeng, T.,Shi, X.,Yuan, C.,Andreasen, P.A.,Huang, M. Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1 J.Biol.Chem., 290:25795-25804, 2015 Cited by PubMed: 26324706 DOI: 10.1074/jbc.M115.677567 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.16 Å)

Structure validation