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2JUM	ThrA3-DKP-insulin Descriptor: Insulin A chain, Insulin B chain Authors: Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2007-08-31 Release date: 2007-10-16 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE. J.Biol.Chem., 282, 2007
2JUU	allo-ThrA3 DKP-insulin Descriptor: Insulin A chain, Insulin B chain Authors: Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2007-09-03 Release date: 2007-10-16 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE. J.Biol.Chem., 282, 2007
2JUV	AbaA3-DKP-insulin Descriptor: Insulin A chain, Insulin B chain Authors: Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2007-09-05 Release date: 2007-10-16 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE. J.Biol.Chem., 282, 2007
2JZQ	Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures Descriptor: Insulin Authors: Hua, Q.X, Nakarawa, S, Jia, W.H, Huang, K, Philips, N.F, Hu, S.Q, Weiss, M.A. Deposit date: 2008-01-11 Release date: 2008-02-26 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J.Biol.Chem., 283, 2008
2JMN	NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures Descriptor: Insulin A chain, Insulin B chain Authors: Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2006-11-21 Release date: 2006-12-05 Last modified: 2023-12-20 Method: SOLUTION NMR Cite: Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J.Mol.Biol., 264, 1996
2KJJ	Dynamics of insulin probed by 1H-NMR amide proton exchange anomalous flexibility of the receptor-binding surface Descriptor: Insulin Authors: Hua, Q.X, Weiss, M.A. Deposit date: 2009-05-29 Release date: 2010-06-16 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Dynamics of Insulin Probed by 1H-NMR Amide Proton E Anomalous Flexibility of the Receptor-Binding Surfa To be Published
2K9R	Enhancing the activity of insulin by stereospecific unfolding Descriptor: Insulin Authors: Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2008-10-23 Release date: 2008-11-11 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284, 2009
2K91	Enhancing the activity of insulin by stereospecific unfolding Descriptor: Insulin Authors: Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2008-09-29 Release date: 2008-11-18 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284, 2009
2KQQ	NMR structure of human insulin mutant gly-b8-d-ala, his-b10-asp, pro-b28-lys, lys-b29-pro, 20 structures Descriptor: Insulin A chain, Insulin B chain Authors: Hua, Q.X, Wan, Z.L, Zhao, M, Jia, W, Huang, K, Weiss, M.A. Deposit date: 2009-11-13 Release date: 2010-11-24 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog. To be Published
2KJU	NMR structure of human insulin mutant glu-b21-d-glu, his-b10 asp pro-b28-lys, lys-b29-pro, 20 structures Descriptor: Insulin Authors: Hua, Q.X, Huang, K, Hu, S.Q, Katsoyanni, P, Weiss, M.A. Deposit date: 2009-06-10 Release date: 2010-06-16 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn To be Published
2KQP	NMR Structure of Proinsulin Descriptor: Insulin Authors: Yang, Y, Hua, Q.X, Mackin, R.B, Weiss, M.A. Deposit date: 2009-11-12 Release date: 2010-01-26 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Solution structure of proinsulin: connecting domain flexibility and prohormone processing. J.Biol.Chem., 285, 2010
2KXK	Human Insulin Mutant A22Gly-B31Lys-B32Arg Descriptor: Insulin A chain, Insulin B chain Authors: Bocian, W, Kozerski, L. Deposit date: 2010-05-07 Release date: 2011-06-01 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Novel recombinant insulin analogue with flexible C - terminus in B chain. NMR structure of biosynthetic engineered A22G-B31K-B32R human insulin monomer in water /acetonitrile solution. To be Published
2L1Z	NMR Structure of human insulin mutant GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 Structures Descriptor: Insulin A chain, Insulin B chain Authors: Wan, Z.L, Hua, Q.X, Huang, K, Hu, S.Q, Philips, N.B, Katsoyannis, J.W, Weiss, M.A. Deposit date: 2010-08-09 Release date: 2011-08-31 Last modified: 2020-02-05 Method: SOLUTION NMR Cite: Chiral Protein Engineering and its Application in G Health To be Published
2L1Y	NMR Structure of human insulin mutant GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 Structures Descriptor: Insulin A chain, Insulin B chain Authors: Wan, Z.L, Hua, Q.X, Huang, K, Hu, S.Q, Philips, N.B, Katsoyannis, J.W, Weiss, M.A. Deposit date: 2010-08-09 Release date: 2011-08-31 Method: SOLUTION NMR Cite: Chiral Protein Engineering and its Application in G Health To be Published
2LGB	Modified A22Gly-B31Arg Human Insulin Descriptor: Insulin A chain, Insulin B chain Authors: Bocian, W, Kozerski, L. Deposit date: 2011-07-25 Release date: 2012-04-11 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Recombinant A22(G)-B31 (R)-human insulin. A22 addition introduces conformational mobility in B chain C-terminus. J.Biomol.Nmr, 52, 2012
2M2N	Structure of [L-HisB24] insulin analogue at pH 8.0 Descriptor: Insulin A chain, Insulin B chain Authors: Zakova, L, Veverka, V, Jiracek, J. Deposit date: 2012-12-29 Release date: 2013-03-06 Last modified: 2013-06-05 Method: SOLUTION NMR Cite: Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2M1E	Biosynthetic engineered B28K-B29P human insulin monomer structure in in water solutions. Descriptor: Insulin Authors: Bocian, W, Kozerski, L. Deposit date: 2012-11-26 Release date: 2013-02-27 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions. J.Biomol.Nmr, 55, 2013
2MLI	NMR structure of B25-(alpha, beta)-dehydro-phenylalanine insulin Descriptor: Insulin Authors: Yang, Y, Weiss, M. Deposit date: 2014-02-27 Release date: 2014-08-20 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
2M2O	Structure of [D-HisB24] insulin analogue at pH 1.9 Descriptor: Insulin A chain, Insulin B chain Authors: Zakova, L, Veverka, V, Jiracek, J. Deposit date: 2012-12-29 Release date: 2013-03-06 Last modified: 2013-06-05 Method: SOLUTION NMR Cite: Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2LWZ	NMR Structures of Single-chain Insulin Descriptor: SINGLE-CHAIN INSULIN Authors: Weiss, M.A, Yang, Y. Deposit date: 2012-08-09 Release date: 2013-08-28 Method: SOLUTION NMR Cite: Dynamic repair of an amyloidogenic protein: Insulin fibrillation is blocked by tethering a nascent alpha-helix To be Published
2M1D	Biosynthetic engineered B28K-B29P human insulin monomer structure in in water/acetonitrile solutions. Descriptor: Insulin Authors: Bocian, W, Kozerski, L. Deposit date: 2012-11-26 Release date: 2013-02-27 Last modified: 2013-05-22 Method: SOLUTION NMR Cite: Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions. J.Biomol.Nmr, 55, 2013
2M2P	Structure of [D-HisB24] insulin analogue at pH 8.0 Descriptor: Insulin A chain, Insulin B chain Authors: Zakova, L, Veverka, V, Jiracek, J. Deposit date: 2012-12-29 Release date: 2013-03-06 Last modified: 2013-06-05 Method: SOLUTION NMR Cite: Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2M2M	Structure of [L-HisB24] insulin analogue at pH 1.9 Descriptor: Insulin A chain, Insulin B chain Authors: Zakova, L, Veverka, V, Jiracek, J. Deposit date: 2012-12-28 Release date: 2013-03-06 Last modified: 2013-06-05 Method: SOLUTION NMR Cite: Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2N2X	Solution structure of [GlyB24,B27-B29 triazole cross-linked]-insulin analogue at pH 1.9 Descriptor: Insulin A chain, Insulin B chain Authors: Veverka, V, Hexnerova, R, Jiracek, J. Deposit date: 2015-05-15 Release date: 2016-02-03 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
2N2W	Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 8.0 Descriptor: Insulin A chain, Insulin B chain Authors: Veverka, V, Hexnerova, R, Jiracek, J. Deposit date: 2015-05-15 Release date: 2016-02-03 Method: SOLUTION NMR Cite: Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016

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