Structure of [L-HisB24] insulin analogue at pH 8.0

Summary for 2M2N

Related2M2M 2M2O 2M2P
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordsinsulin, hormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5808.62
Zakova, L.,Veverka, V.,Jiracek, J. (deposition date: 2012-12-29, release date: 2013-03-06, Last modification date: 2013-06-05)
Primary citation
Kletvikova, E.,Veverka, V.,Lepsik, M.,Watson, C.J.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.
Structural integrity of the B24 site in human insulin is important for hormone functionality.
J.Biol.Chem., 288:10230-10240, 2013
PubMed: 23447530 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.448050
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers02.9%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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