2M2N

Structure of [L-HisB24] insulin analogue at pH 8.0

Summary for 2M2N

Related2M2M 2M2O 2M2P
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordsinsulin, hormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5808.62
Authors
Zakova, L.,Veverka, V.,Jiracek, J. (deposition date: 2012-12-29, release date: 2013-03-06, Last modification date: 2013-06-05)
Primary citation
Kletvikova, E.,Veverka, V.,Lepsik, M.,Watson, C.J.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.
Structural integrity of the B24 site in human insulin is important for hormone functionality.
J.Biol.Chem., 288:10230-10240, 2013
PubMed: 23447530 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.448050
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers02.9%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2m2n
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Molmil generated image of 2m2n
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Molmil generated image of 2m2n
rotated about y axis by 90°