2K9R

Enhancing the activity of insulin by stereospecific unfolding

Summary for 2K9R

Related2K91
DescriptorInsulin (2 entities in total)
Functional Keywordshormone, insulin, mutant, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, pharmaceutical, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5718.5
Authors
Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakarawa, S.,Jia, W.H.,Philips, N.F.P.,Wittaker, L.,Wittaker, J.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2008-10-23, release date: 2008-11-11, Last modification date: 2011-07-13)
Primary citation
Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakagawa, S.,Jia, W.,Wang, S.,Whittaker, J.,Katsoyannis, P.G.,Weiss, M.A.
Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284:14586-14596, 2009
PubMed: 19321436 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M900085200
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers11510.7%38.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2k9r
no rotation
Molmil generated image of 2k9r
rotated about x axis by 90°
Molmil generated image of 2k9r
rotated about y axis by 90°