Enhancing the activity of insulin by stereospecific unfolding

Summary for 2K9R

DescriptorInsulin (2 entities in total)
Functional Keywordshormone, insulin, mutant, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, pharmaceutical, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5718.5
Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakarawa, S.,Jia, W.H.,Philips, N.F.P.,Wittaker, L.,Wittaker, J.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2008-10-23, release date: 2008-11-11, Last modification date: 2011-07-13)
Primary citation
Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakagawa, S.,Jia, W.,Wang, S.,Whittaker, J.,Katsoyannis, P.G.,Weiss, M.A.
Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284:14586-14596, 2009
PubMed: 19321436 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M900085200
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers115 10.7% 38.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-10-21