2JMN

NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures

Replaces:  1LNP

Summary for 2JMN

Related2H67
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordshormone, human insulin, mutant, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5794.59
Authors
Hua, Q.X.,Hu, S.Q.,Frank, B.H.,Jia, W.H.,Chu, Y.C.,Wang, S.H.,Burke, G.T.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2006-11-21, release date: 2006-12-05, Last modification date: 2011-07-13)
Primary citation
Hua, Q.X.,Hu, S.Q.,Frank, B.H.,Jia, W.,Chu, Y.C.,Wang, S.H.,Burke, G.T.,Katsoyannis, P.G.,Weiss, M.A.
Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264:390-403, 1996
PubMed: 8951384 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1996.0648
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers944.7%25.9%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2jmn
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Molmil generated image of 2jmn
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Molmil generated image of 2jmn
rotated about y axis by 90°