NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures

Replaces:  1LNP

Summary for 2JMN

DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordshormone, human insulin, mutant, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5794.59
Hua, Q.X.,Hu, S.Q.,Frank, B.H.,Jia, W.H.,Chu, Y.C.,Wang, S.H.,Burke, G.T.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2006-11-21, release date: 2006-12-05, Last modification date: 2011-07-13)
Primary citation
Hua, Q.X.,Hu, S.Q.,Frank, B.H.,Jia, W.,Chu, Y.C.,Wang, S.H.,Burke, G.T.,Katsoyannis, P.G.,Weiss, M.A.
Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264:390-403, 1996
PubMed: 8951384 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1996.0648
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers94 4.7% 25.9%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-10-21