2H67

NMR structure of human insulin mutant HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures

Summary for 2H67

DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordshormone, human insulin, mutant, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5727.52
Authors
Hua, Q.X.,Liu, M.,Hu, S.Q.,Jia, W.,Arvan, P.,Weiss, M.A. (deposition date: 2006-05-30, release date: 2006-07-18, Last modification date: 2011-07-13)
Primary citation
Hua, Q.X.,Liu, M.,Hu, S.Q.,Jia, W.,Arvan, P.,Weiss, M.A.
A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: Structure and function of an Alab5 analog.
J.Biol.Chem., 281:24889-24899, 2006
PubMed: 16728398 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M602617200
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers748.0%29.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures