4BKA
 
 | | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 | | Descriptor: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 | | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | | Deposit date: | 2013-04-23 | | Release date: | 2013-07-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (5.3 Å) | | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20, 2013
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4BK4
 | | crystal structure of the human EphA4 ectodomain | | Descriptor: | EPHRIN TYPE-A RECEPTOR 4 | | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | | Deposit date: | 2013-04-22 | | Release date: | 2013-07-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.65 Å) | | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20, 2013
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4BQ6
 | | Crystal structure of the RGMB-NEO1 complex form 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NEOGENIN, RGM DOMAIN FAMILY MEMBER B | | Authors: | Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | | Deposit date: | 2013-05-30 | | Release date: | 2013-06-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub
Science, 341, 2013
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1ERN
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1CN4
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1EBA
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1EBP
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1EER
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1F6F
 | | CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR | | Descriptor: | PLACENTAL LACTOGEN, PROLACTIN RECEPTOR | | Authors: | Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. | | Deposit date: | 2000-06-21 | | Release date: | 2000-07-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
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3L5H
 | | Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly of receptor complexes | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6 receptor subunit beta, SULFATE ION, ... | | Authors: | Xu, Y, Garrett, T.P.J, Zhang, J.G. | | Deposit date: | 2009-12-21 | | Release date: | 2010-05-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.
J.Biol.Chem., 285, 2010
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8PB1
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-06-08 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8Q6T
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3N1G
 | | Crystal structure of DhhN bound to BOCFn3 | | Descriptor: | Brother of CDO, CALCIUM ION, Desert hedgehog protein, ... | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-15 | | Release date: | 2010-06-02 | | Last modified: | 2023-07-26 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
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8QY4
 | | Structure of interleukin 11 (gp130 P496L mutant). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... | | Authors: | Gardner, S, Bubeck, D, Jin, Y. | | Deposit date: | 2023-10-25 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structure of interleukin 11 (gp130 P496L mutant).
To Be Published
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8QY5
 | | Structure of interleukin 6. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... | | Authors: | Gardner, S, Bubeck, D, Jin, Y. | | Deposit date: | 2023-10-25 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of interleukin 6.
To Be Published
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8QY6
 | | Structure of interleukin 6 (gp130 P496L mutant). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... | | Authors: | Gardner, S, Bubeck, D, Jin, Y. | | Deposit date: | 2023-10-25 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Structure of interleukin 6 (gp130 P496L mutant).
To Be Published
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5FM5
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5FMV
 | | Crystal structure of human CD45 extracellular region, domains d1-d4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION | | Authors: | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | | Deposit date: | 2015-11-09 | | Release date: | 2016-03-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
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5FN6
 | | Crystal structure of human CD45 extracellular region, domains d1-d3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C | | Authors: | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | | Deposit date: | 2015-11-10 | | Release date: | 2016-03-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
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3NPZ
 | | Prolactin Receptor (PRLR) Complexed with the Natural Hormone (PRL) | | Descriptor: | Prolactin, Prolactin receptor | | Authors: | Van Agthoven, J, England, P, Goffin, V, Broutin, I. | | Deposit date: | 2010-06-29 | | Release date: | 2010-10-06 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone.
J.Mol.Biol., 404, 2010
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8TAN
 | | CryoEM structure of MFRV-VILP bound to IGF1Rzip | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ... | | Authors: | Kirk, N.S. | | Deposit date: | 2023-06-27 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.
Mol Metab, 80, 2024
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2JIX
 | | Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor | | Descriptor: | ABT-007 FAB FRAGMENT, ERYTHROPOIETIN RECEPTOR | | Authors: | Liu, Z, Stoll, V.S, DeVries, P, Jakob, C.G, Xie, N, Simmer, R.L, Lacy, S.E, Egan, D.A, Harlan, J.E, Lesniewski, R.R, Reilly, E.B. | | Deposit date: | 2007-07-02 | | Release date: | 2007-07-10 | | Last modified: | 2020-03-18 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A Potent Erythropoietin-Mimicking Human Antibody Interacts Through a Novel Binding Site.
Blood, 110, 2007
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3MTR
 | | Crystal structure of the Ig5-FN1 tandem of human NCAM | | Descriptor: | Neural cell adhesion molecule 1, SULFATE ION | | Authors: | Lavie, A, Foley, D.A. | | Deposit date: | 2010-04-30 | | Release date: | 2010-06-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites
J.Biol.Chem., 285, 2010
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2JLL
 | | Crystal structure of NCAM2 IgIV-FN3II | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | | Authors: | Kulahin, N, Rasmussen, K, Kristensen, O, Kastrup, J, Berezin, V, Bock, E, Walmod, P, Gajhede, M. | | Deposit date: | 2008-09-10 | | Release date: | 2009-11-17 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Model and Trans-Interaction of the Entire Ectodomain of the Olfactory Cell Adhesion Molecule.
Structure, 19, 2011
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3MX0
 | | Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 2, ... | | Authors: | Himanen, J.P, Yermekbayeva, L, Janes, P.W, Walker, J.R, Xu, K, Atapattu, L, Rajashankar, K.R, Mensinga, A, Lackmann, M, Nikolov, D.B, Dhe-Paganon, S. | | Deposit date: | 2010-05-06 | | Release date: | 2010-06-30 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.506 Å) | | Cite: | Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
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