1CN4

ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR

Replaces:  1BLW

Summary for 1CN4

• Entry DOI: 10.2210/pdb1cn4/pdb
• Descriptor: PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (ERYTHROPOIETIN) (3 entities in total)
• Functional Keywords: hematopoietic cytokine, cytokine receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted : P19235; Secreted: P01588
• Total number of polymer chains: 3
• Total formula weight: 69011.48

Authors

Stroud, R.M.,Reid, S.W. (deposition date: 1999-05-25, release date: 1999-08-11, Last modification date: 2023-12-27)

• Primary citation: Syed, R.S.,Reid, S.W.,Li, C.,Cheetham, J.C.,Aoki, K.H.,Liu, B.,Zhan, H.,Osslund, T.D.,Chirino, A.J.,Zhang, J.,Finer-Moore, J.,Elliott, S.,Sitney, K.,Katz, B.A.,Matthews, D.J.,Wendoloski, J.J.,Egrie, J.,Stroud, R.M.; Efficiency of signalling through cytokine receptors depends critically on receptor orientation.; Nature, 395:511-516, 1998; PubMed: 9774108; DOI: 10.1038/26773

Experimental method

X-RAY DIFFRACTION (2.8 Å)