4BKA

crystal structure of the human EphA4 ectodomain in complex with human ephrin A5

Summary for 4BKA

Related4BK4 4BK5 4BKB
DescriptorEPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 (2 entities in total)
Functional Keywordscell adhesion, cell repulsion, receptor clustering, receptor cis interaction, eph-ephrin, eph ectodomain, erythropoetin-producing hepatocellular receptor, lbd, sushi, egf, fn
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight83338.93
Authors
Seiradake, E.,Schaupp, A.,del Toro Ruiz, D.,Kaufmann, R.,Mitakidis, N.,Harlos, K.,Aricescu, A.R.,Klein, R.,Jones, E.Y. (deposition date: 2013-04-23, release date: 2013-07-03, Last modification date: 2019-04-03)
Primary citation
Seiradake, E.,Schaupp, A.,Del Toro Ruiz, D.,Kaufmann, R.,Mitakidis, N.,Harlos, K.,Aricescu, A.R.,Klein, R.,Jones, E.Y.
Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20:958-, 2013
PubMed: 23812375 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.2617
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (5.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.4079 0.5% 2.5% 19.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report