1EBA

COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN INACTIVE PEPTIDE [EMP33] CONTAINS 3,5-DIBROMOTYROSINE IN POSITION 4 (DENOTED DBY)

Summary for 1EBA

Entry DOI	10.2210/pdb1eba/pdb
Descriptor	PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (EPO MIMETICS PEPTIDE 33) (2 entities in total)
Functional Keywords	erythropoietin receptor, signal transduction, protein minimization, drug design, cytokine receptor class 1, complex (cytokine receptor-peptide), signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235
Total number of polymer chains	4
Total formula weight	51990.15
Authors	Livnah, O.,Stura, E.A.,Wilson, I.A. (deposition date: 1998-10-02, release date: 1998-11-11, Last modification date: 2023-08-09)
Primary citation	Livnah, O.,Johnson, D.L.,Stura, E.A.,Farrell, F.X.,Barbone, F.P.,You, Y.,Liu, K.D.,Goldsmith, M.A.,He, W.,Krause, C.D.,Pestka, S.,Jolliffe, L.K.,Wilson, I.A. An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat.Struct.Biol., 5:993-1004, 1998 Cited by PubMed: 9808045 DOI: 10.1038/2965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation