1EBP

COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1]

Summary for 1EBP

Entry DOI	10.2210/pdb1ebp/pdb
Descriptor	EPO RECEPTOR, EPO MIMETICS PEPTIDE 1 (2 entities in total)
Functional Keywords	erythropoietin receptor, signal transduction, protein minimization, drug design, cytokine receptor class 1, complex (cytokine receptor-peptide), complex (cytokine receptor-peptide) complex, complex (cytokine receptor/peptide)
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235
Total number of polymer chains	4
Total formula weight	50849.69
Authors	Livnah, O.,Stura, E.A.,Wilson, I.A. (deposition date: 1996-05-07, release date: 1997-07-29, Last modification date: 2011-07-13)
Primary citation	Livnah, O.,Stura, E.A.,Johnson, D.L.,Middleton, S.A.,Mulcahy, L.S.,Wrighton, N.C.,Dower, W.J.,Jolliffe, L.K.,Wilson, I.A. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science, 273:464-471, 1996 Cited by PubMed: 8662530 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation