1EER

CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS

Summary for 1EER

Entry DOI	10.2210/pdb1eer/pdb
Descriptor	ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR (3 entities in total)
Functional Keywords	erythropoietin, erythropoietin receptor, signal transduction, hematopoietic cytokine, cytokine receptor class 1, complex (cytokine-receptor), complex (cytokine-receptor) complex, complex (cytokine/receptor)
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01588 Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235
Total number of polymer chains	3
Total formula weight	68844.19
Authors	Syed, R.S.,Li, C. (deposition date: 1998-07-24, release date: 1999-10-01, Last modification date: 2021-11-03)
Primary citation	Syed, R.S.,Reid, S.W.,Li, C.,Cheetham, J.C.,Aoki, K.H.,Liu, B.,Zhan, H.,Osslund, T.D.,Chirino, A.J.,Zhang, J.,Finer-Moore, J.,Elliott, S.,Sitney, K.,Katz, B.A.,Matthews, D.J.,Wendoloski, J.J.,Egrie, J.,Stroud, R.M. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395:511-516, 1998 Cited by PubMed: 9774108 DOI: 10.1038/26773 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation