1EER
CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ERYTHROPOIETIN | polymer | 166 | 18471.3 | 1 | UniProt (P01588) Pfam (PF00758) | Homo sapiens (human) | |
| 2 | B, C (B, C) | ERYTHROPOIETIN RECEPTOR | polymer | 227 | 25186.4 | 2 | UniProt (P19235) Pfam (PF09067) Pfam (PF00041) | Homo sapiens (human) | EPOBP |
| 3 | D, E, F (A, B, C) | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
A: 1 - 166 (UniProt: P01588)
B, C: 7 - 226 (UniProt: P19235)
| PDB | External Database | Details |
|---|---|---|
| Lys 24 | Asn 51 | engineered mutation |
| Lys 38 | Asn 65 | engineered mutation |
| Lys 83 | Asn 110 | engineered mutation |
| Asn 121 | Pro 148 | engineered mutation |
| Ser 122 | Pro 149 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gln 52 | Asn 76 | engineered mutation |
| Gln 164 | Asn 188 | engineered mutation |
| Glu 211 | Ala 235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68844.2 | |
| All* | Total formula weight | 68844.2 |
