8PB1

Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement.

Summary for 8PB1

Entry DOI	10.2210/pdb8pb1/pdb
Related	8cr5 8cr6 8cr7 8cr8 8odx 8odz 8oeO
EMDB information	16820 16821 17580
Descriptor	Interleukin-12 subunit alpha, Interleukin-12 subunit beta, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... (7 entities in total)
Functional Keywords	complex, cytokine, receptor, signaling protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	4
Total formula weight	212910.83
Authors	Felix, J.,Bloch, Y.,Savvides, S.N. (deposition date: 2023-06-08, release date: 2024-02-07)
Primary citation	Bloch, Y.,Felix, J.,Merceron, R.,Provost, M.,Symakani, R.A.,De Backer, R.,Lambert, E.,Mehdipour, A.R.,Savvides, S.N. Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38287195 DOI: 10.1038/s41594-023-01190-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation