8PB1
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement.
Summary for 8PB1
Entry DOI | 10.2210/pdb8pb1/pdb |
Related | 8cr5 8cr6 8cr7 8cr8 8odx 8odz 8oeO |
EMDB information | 16820 16821 17580 |
Descriptor | Interleukin-12 subunit alpha, Interleukin-12 subunit beta, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... (7 entities in total) |
Functional Keywords | complex, cytokine, receptor, signaling protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 212910.83 |
Authors | Felix, J.,Bloch, Y.,Savvides, S.N. (deposition date: 2023-06-08, release date: 2024-02-07, Last modification date: 2024-05-01) |
Primary citation | Bloch, Y.,Felix, J.,Merceron, R.,Provost, M.,Symakani, R.A.,De Backer, R.,Lambert, E.,Mehdipour, A.R.,Savvides, S.N. Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31:591-597, 2024 Cited by PubMed: 38287195DOI: 10.1038/s41594-023-01190-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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