8ODX
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb4 fragment and VHH.
Summary for 8ODX
| Entry DOI | 10.2210/pdb8odx/pdb |
| Related | 8C7M 8CR5 8CR6 8CR8 |
| Descriptor | Interleukin-12 receptor subunit beta-1, FAb4 Heavy chain, anti Kappa Light chain VHH, ... (4 entities in total) |
| Functional Keywords | receptor, fibronectin, antagonist, cytokine |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 110923.17 |
| Authors | Bloch, Y.,Savvides, S.N. (deposition date: 2023-03-09, release date: 2024-02-07, Last modification date: 2024-05-01) |
| Primary citation | Bloch, Y.,Felix, J.,Merceron, R.,Provost, M.,Symakani, R.A.,De Backer, R.,Lambert, E.,Mehdipour, A.R.,Savvides, S.N. Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31:591-597, 2024 Cited by PubMed: 38287195DOI: 10.1038/s41594-023-01190-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (4.4 Å) |
Structure validation
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