8ODX
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb4 fragment and VHH.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-12 receptor subunit beta-1 | polymer | 376 | 40884.9 | 1 | UniProt (P42701) Pfam (PF00041) | Homo sapiens (human) | IL-12 receptor subunit beta-1,IL-12R subunit beta-1,IL-12R-beta-1,IL-12RB1,IL-12 receptor beta component |
| 2 | B (H) | FAb4 Heavy chain | polymer | 250 | 26776.0 | 1 | Homo sapiens x Mus musculus hybrid cell line | ||
| 3 | C (K) | anti Kappa Light chain VHH | polymer | 167 | 18058.0 | 1 | Lama glama | ||
| 4 | D (L) | FAb4 Light chain | polymer | 231 | 25204.2 | 1 | Homo sapiens x Mus musculus hybrid cell line |
Sequence modifications
A: 232 - 540 (UniProt: P42701)
| PDB | External Database | Details |
|---|---|---|
| Met 203 | - | initiating methionine |
| Gly 204 | - | expression tag |
| Ile 205 | - | expression tag |
| Leu 206 | - | expression tag |
| Pro 207 | - | expression tag |
| Ser 208 | - | expression tag |
| Pro 209 | - | expression tag |
| Gly 210 | - | expression tag |
| Met 211 | - | expression tag |
| Pro 212 | - | expression tag |
| Ala 213 | - | expression tag |
| Leu 214 | - | expression tag |
| Leu 215 | - | expression tag |
| Ser 216 | - | expression tag |
| Leu 217 | - | expression tag |
| Val 218 | - | expression tag |
| Ser 219 | - | expression tag |
| Leu 220 | - | expression tag |
| Leu 221 | - | expression tag |
| Ser 222 | - | expression tag |
| Val 223 | - | expression tag |
| Leu 224 | - | expression tag |
| Leu 225 | - | expression tag |
| Met 226 | - | expression tag |
| Gly 227 | - | expression tag |
| Cys 228 | - | expression tag |
| Val 229 | - | expression tag |
| Ala 230 | - | expression tag |
| Glu 231 | - | expression tag |
| Gly 541 | - | expression tag |
| Thr 542 | - | expression tag |
| Ser 543 | - | expression tag |
| Asp 544 | - | expression tag |
| Glu 545 | - | expression tag |
| Val 546 | - | expression tag |
| Asp 547 | - | expression tag |
| Gly 548 | - | expression tag |
| Gly 549 | - | expression tag |
| Ser 550 | - | expression tag |
| Gly 551 | - | expression tag |
| Gly 552 | - | expression tag |
| Ser 553 | - | expression tag |
| Gly 554 | - | expression tag |
| Leu 555 | - | expression tag |
| Asn 556 | - | expression tag |
| Asp 557 | - | expression tag |
| Ile 558 | - | expression tag |
| Phe 559 | - | expression tag |
| Glu 560 | - | expression tag |
| Ala 561 | - | expression tag |
| Gln 562 | - | expression tag |
| Lys 563 | - | expression tag |
| Ile 564 | - | expression tag |
| Glu 565 | - | expression tag |
| Trp 566 | - | expression tag |
| His 567 | - | expression tag |
| Glu 568 | - | expression tag |
| Gly 569 | - | expression tag |
| Arg 570 | - | expression tag |
| Thr 571 | - | expression tag |
| Lys 572 | - | expression tag |
| His 573 | - | expression tag |
| His 574 | - | expression tag |
| His 575 | - | expression tag |
| His 576 | - | expression tag |
| His 577 | - | expression tag |
| His 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 110923.2 | |
| All* | Total formula weight | 110923.2 |
