3VRY
| Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Descriptor: | 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Tomabechi, Y, Niwa, H, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.481 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
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1CSK
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2ABL
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1M27
| Crystal structure of SAP/FynSH3/SLAM ternary complex | Descriptor: | CITRATE ANION, Proto-oncogene tyrosine-protein kinase FYN, SH2 domain protein 1A, ... | Authors: | Chan, B, Griesbach, J, Song, H.K, Poy, F, Terhorst, C, Eck, M.J. | Deposit date: | 2002-06-21 | Release date: | 2003-05-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | SAP couples Fyn to SLAM immune receptors. NAT.CELL BIOL., 5, 2003
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6SDF
| N-terminal SH3 domain of Grb2 protein | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Growth factor receptor-bound protein 2 | Authors: | Bolgov, A.A, Korban, S.A, Luzik, D.A, Rogacheva, O.N, Zhemkov, V.A, Kim, M, Skrynnikov, N.R, Bezprozvanny, I.B. | Deposit date: | 2019-07-26 | Release date: | 2020-01-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the SH3 domain of growth factor receptor-bound protein 2. Acta Crystallogr.,Sect.F, 76, 2020
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1LCK
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1EFN
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7YXW
| Structure of the p22phox A200G mutant in complex with p47phox peptide | Descriptor: | Cytochrome b-245 light chain, Neutrophil cytosol factor 1 | Authors: | Cukier, C.D, Vuillard, L.M, Komjati, B, Szlavik, Z. | Deposit date: | 2022-02-16 | Release date: | 2022-03-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics Acs Med.Chem.Lett., 13, 2022
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1K9A
| Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution | Descriptor: | Carboxyl-terminal Src kinase | Authors: | Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T. | Deposit date: | 2001-10-28 | Release date: | 2002-03-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the carboxyl-terminal Src kinase, Csk. J.Biol.Chem., 277, 2002
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1AOJ
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1B07
| CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR | Descriptor: | PHENYLETHANE, PROTEIN (PROTO-ONCOGENE CRK (CRK)), PROTEIN (SH3 PEPTOID INHIBITOR) | Authors: | Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A. | Deposit date: | 1998-11-17 | Release date: | 1999-01-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science, 282, 1998
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1WDX
| Yeast BBC1 SH3 domain, triclinic crystal form | Descriptor: | Myosin tail region-interacting protein MTI1 | Authors: | Wilmanns, M, Consani Textor, L, Kursula, P, Kursula, I, Lehmann, F, Song, Y.H. | Deposit date: | 2004-05-19 | Release date: | 2005-05-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of Yeast BBC1 SH3 domain, triclinic crystal form To be Published
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3QWY
| CED-2 | Descriptor: | Cell death abnormality protein 2, GLYCEROL, SULFATE ION | Authors: | Kang, Y, Sun, J, Liu, Y, Sun, D, Hu, Y, Liu, Y.F. | Deposit date: | 2011-02-28 | Release date: | 2011-06-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
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4D8D
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2CDT
| alpha-SPECTRIN SH3 DOMAIN A56S MUTANT | Descriptor: | SPECTRIN ALPHA CHAIN | Authors: | Casares, S, Camara-Artigas, A, Vega, M.C, Lopez-Mayorga, O, Conejero-Lara, F. | Deposit date: | 2006-01-27 | Release date: | 2007-02-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Cooperative Propagation of Local Stability Changes from Low-Stability and High-Stability Regions in a SH3 Domain. Proteins: Struct., Funct., Bioinf., 67, 2007
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8T7C
| Crystal structure of human phospholipase C gamma 2 | Descriptor: | 1,2-ETHANEDIOL, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, CALCIUM ION | Authors: | Chen, Y, Choi, H, Zhuang, N, Hu, L, Qian, D, Wang, J. | Deposit date: | 2023-06-20 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition To Be Published
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7UY0
| Crystal structure of human Fgr tyrosine kinase in complex with A-419259 | Descriptor: | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ... | Authors: | Du, S, Alvarado, J.J, Smithgall, T.E. | Deposit date: | 2022-05-06 | Release date: | 2022-12-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022
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3EHQ
| Crystal Structure of Human Osteoclast Stimulating Factor | Descriptor: | 1,2-ETHANEDIOL, Osteoclast-stimulating factor 1 | Authors: | Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. | Deposit date: | 2008-09-14 | Release date: | 2009-08-04 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Crystal structure of human osteoclast stimulating factor Proteins, 75, 2009
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7UD6
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3M0P
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4XI2
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1G83
| CRYSTAL STRUCTURE OF FYN SH3-SH2 | Descriptor: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN | Authors: | Arold, S.T, Ulmer, T.S, Mulhern, T.D, Werner, J.M, Ladbury, J.E, Campbell, I.D, Noble, M.E.M. | Deposit date: | 2000-11-16 | Release date: | 2001-05-30 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J.Biol.Chem., 276, 2001
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1UUE
| a-SPECTRIN SH3 DOMAIN (V44T, D48G MUTANT) | Descriptor: | SPECTRIN ALPHA CHAIN | Authors: | Vega, M.C, Fernandez, A, Wilmanns, M, Serrano, L. | Deposit date: | 2003-12-18 | Release date: | 2004-02-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Solvation in Protein Folding Analysis: Combination of Theoretical and Experimental Approaches Proc.Natl.Acad.Sci.USA, 101, 2004
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1AD5
| SRC FAMILY KINASE HCK-AMP-PNP COMPLEX | Descriptor: | CALCIUM ION, HAEMATOPOETIC CELL KINASE HCK, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Sicheri, F, Moarefi, I, Kuriyan, J. | Deposit date: | 1997-02-20 | Release date: | 1997-05-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the Src family tyrosine kinase Hck. Nature, 385, 1997
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1BU1
| SRC FAMILY KINASE HCK SH3 DOMAIN | Descriptor: | PROTEIN (HEMOPOIETIC CELL KINASE) | Authors: | Arold, S, Franken, P, Dumas, C. | Deposit date: | 1998-09-09 | Release date: | 1998-11-11 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef. Biochemistry, 37, 1998
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