1AOJ

THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER

Summary for 1AOJ

Entry DOI	10.2210/pdb1aoj/pdb
Descriptor	EPS8 (2 entities in total)
Functional Keywords	signal transduction, sh3 domain, eps8, proline rich peptide
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	14089.92
Authors	Kishan, K.V.R.,Newcomer, M.E. (deposition date: 1997-07-07, release date: 1998-07-08, Last modification date: 2024-05-22)
Primary citation	Kishan, K.V.,Scita, G.,Wong, W.T.,Di Fiore, P.P.,Newcomer, M.E. The SH3 domain of Eps8 exists as a novel intertwined dimer. Nat.Struct.Biol., 4:739-743, 1997 Cited by PubMed Abstract: SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif. PubMed: 9303002 DOI: 10.1038/nsb0997-739 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation