7YXW

Structure of the p22phox A200G mutant in complex with p47phox peptide

Summary for 7YXW

• Entry DOI: 10.2210/pdb7yxw/pdb
• Descriptor: Cytochrome b-245 light chain, Neutrophil cytosol factor 1 (2 entities in total)
• Functional Keywords: nadph oxidase complex, oxidoreductase activator, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 16581.51

Authors

Cukier, C.D.,Vuillard, L.M.,Komjati, B.,Szlavik, Z. (deposition date: 2022-02-16, release date: 2022-03-30, Last modification date: 2024-01-31)

• Primary citation: Garsi, J.B.,Komjati, B.,Cullia, G.,Fejes, I.,Sipos, M.,Sipos, Z.,Fordos, E.,Markacz, P.,Balazs, B.,Lancelot, N.,Berger, S.,Raimbaud, E.,Brown, D.,Vuillard, L.M.,Haberkorn, L.,Cukier, C.,Szlavik, Z.,Hanessian, S.; Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics; Acs Med.Chem.Lett., 13:949-954, 2022; DOI: 10.1021/acsmedchemlett.2c00094

Experimental method

X-RAY DIFFRACTION (2.5 Å)