7UY0

Crystal structure of human Fgr tyrosine kinase in complex with A-419259

Summary for 7UY0

Entry DOI	10.2210/pdb7uy0/pdb
Descriptor	Tyrosine-protein kinase Fgr, GLYCEROL, 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (7 entities in total)
Functional Keywords	fgr, a-419259, signaling protein, kinase, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	106131.91
Authors	Du, S.,Alvarado, J.J.,Smithgall, T.E. (deposition date: 2022-05-06, release date: 2022-12-28, Last modification date: 2023-11-15)
Primary citation	Du, S.,Alvarado, J.J.,Wales, T.E.,Moroco, J.A.,Engen, J.R.,Smithgall, T.E. ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30:1508-1517.e3, 2022 Cited by PubMed: 36115344 DOI: 10.1016/j.str.2022.08.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation