7UY0
Crystal structure of human Fgr tyrosine kinase in complex with A-419259
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Fgr | polymer | 456 | 52241.3 | 1 | UniProt (P09769) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog,Proto-oncogene c-Fgr,p55-Fgr,p58-Fgr,p58c-Fgr |
| 2 | B (B) | Tyrosine-protein kinase Fgr | polymer | 456 | 52317.4 | 1 | UniProt (P09769) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog,Proto-oncogene c-Fgr,p55-Fgr,p58-Fgr,p58c-Fgr |
| 3 | C, D, G (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | E, H (A, B) | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | non-polymer | 482.6 | 2 | Chemie (VSE) | |||
| 5 | F, I, J, K (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 6 | L, M (B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | N, O (A, B) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 84 - 531 (UniProt: P09769)
B: 84 - 531 (UniProt: P09769)
| PDB | External Database | Details |
|---|---|---|
| Met 76 | - | initiating methionine |
| Gly 77 | - | expression tag |
| His 78 | - | expression tag |
| His 79 | - | expression tag |
| His 80 | - | expression tag |
| His 81 | - | expression tag |
| His 82 | - | expression tag |
| His 83 | - | expression tag |
| Glu 528 | Gln 524 | engineered mutation |
| Glu 529 | Pro 525 | engineered mutation |
| Ile 530 | Gly 526 | engineered mutation |
| Pro 531 | Asp 527 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 76 | - | initiating methionine |
| Gly 77 | - | expression tag |
| His 78 | - | expression tag |
| His 79 | - | expression tag |
| His 80 | - | expression tag |
| His 81 | - | expression tag |
| His 82 | - | expression tag |
| His 83 | - | expression tag |
| Glu 528 | Gln 524 | engineered mutation |
| Glu 529 | Pro 525 | engineered mutation |
| Ile 530 | Gly 526 | engineered mutation |
| Pro 531 | Asp 527 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 104558.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1573.3 | |
| All* | Total formula weight | 106131.9 |
