7UD6
Designed Enzyme SH3-588 (Catechol O-methyltransferase catalytic domain and Src homology 3 binding domain fusion)
Summary for 7UD6
| Entry DOI | 10.2210/pdb7ud6/pdb |
| Descriptor | Tyrosine-protein kinase Fyn,Catechol O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, POTASSIUM ION, ... (4 entities in total) |
| Functional Keywords | designed enzyme, comt, sh3, fusion protein, transferase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 33057.52 |
| Authors | Ongpipattanakul, C.,Nair, S.K. (deposition date: 2022-03-18, release date: 2023-01-11, Last modification date: 2023-10-25) |
| Primary citation | Park, R.,Ongpipattanakul, C.,Nair, S.K.,Bowers, A.A.,Kuhlman, B. Designer installation of a substrate recruitment domain to tailor enzyme specificity. Nat.Chem.Biol., 19:460-467, 2023 Cited by PubMed: 36509904DOI: 10.1038/s41589-022-01206-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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