7UD6

Designed Enzyme SH3-588 (Catechol O-methyltransferase catalytic domain and Src homology 3 binding domain fusion)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008171	molecular_function	O-methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01019, ECO:0000269|PubMed:12237326

Chain	Residue	Details
A	VAL104
A	SER134
A	GLU152
A	ASP203

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01019

Chain	Residue	Details
A	GLU126
A	ILE153
A	SER181

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	GLY179
A	LYS206
A	ASP231
A	ASN232
A	GLU261

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 915

Chain	Residue	Details
A	ASP203	metal ligand
A	LYS206	proton shuttle (general acid/base)
A	ASP231	metal ligand
A	ASN232	metal ligand
A	GLU261	electrostatic stabiliser

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